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首页> 外文期刊>Biotechnology Progress >Economic Comparison of Diagnostic Antibody Production in Perfusion Stirred Tank and in Hollow Fiber Bioreactor Processes
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Economic Comparison of Diagnostic Antibody Production in Perfusion Stirred Tank and in Hollow Fiber Bioreactor Processes

机译：灌注搅拌罐和中空纤维生物反应器过程中诊断抗体生产的经济比较

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The total operating costs of small-scale monoclonal antibody production were calculated for two different upstream options and general downstream procedure based on protein A chromatography. The upstream options were a spin-filter equipped stirred-tank bioreactor (STR) and a hollow fiber bioreactor (HFB). Both the bioreactors were operated in perfusion mode. The total operating costs of the processes were 6,900 ?/g for STR option and 6,400 ?/g for the HFB option. In the both systems, the costs were dominated by expenses derived from the downstream section (almost 80%) that was almost identical in the both systems. In the upstream section, the investment depreciation was the largest cost item. The lower total costs of the HFB option were a result of lower investment costs and more concentrated product that led into savings also in downstream section. This study brings out the HFB as on viable alternative for stirred-tank bioreactor, especially in small-scale diagnostic monoclonal antibody production.
机译：针对两种不同的上游选项和基于蛋白质A色谱的一般下游程序，计算了小规模单克隆抗体生产的总运营成本。上游选项是配备有旋转过滤器的搅拌釜式生物反应器（STR）和中空纤维生物反应器（HFB）。两个生物反应器均以灌注模式操作。 STR选件的工艺总运行成本为6900 // g，HFB选件的总运行成本为6400 // g。在这两个系统中，成本主要来自下游部分（几乎80％）的支出，这两个系统几乎相同。在上游部分，投资折旧是最大的成本项目。 HFB选件的总成本较低是由于较低的投资成本和更集中的产品所致，这也导致了下游部门的节省。这项研究提出了HFB作为搅拌罐式生物反应器的可行替代品，特别是在小规模诊断性单克隆抗体生产中。

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