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首页> 外文期刊>Journal of neurosurgical sciences >Primary multifocal myxopapillary ependymoma of the filum terminale
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Primary multifocal myxopapillary ependymoma of the filum terminale

机译：Filum inderme的主要多焦体肌瘤外膜瘤

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BACKGROUND: Myxopapillary ependymoma (MPE) is a rare variant of ependymoma usually occurring in the conus medullaris or the filum terminale. It is usually a single encapsulated lesion. The aim of this study was to describe patients with primary multifocal MPE of the filum terminale.METHODS: In this retrospective study, medical records of 22 patients with spinal MPE who underwent surgical treatment in our hospital between January 2003 and January 2010 were enrolled. The study included 14 males and 8 females with age range from 11 to 66 years. There were 14 adult patients and 8 pediatric patients. The clinical presentation was low back pain (LBP), radiculopathy, focal neurological deficit and cranial nerve palsy.RESULT: Four cases presented with primary multifocal MPE at the filum terminale. All of them had chronic LBP for at least 2-3 years. Three patients had lower extremity radiculopathy and one had urinary incontinence upon presentation. On magnetic resonance imaging (MRI), three patients presented with two lesions and one patient presented with three lesions at different spinal levels (a total of 9 MPEs). All lesions showed enhancement following gadolinium administration on MRI. For 6 tumors en bloc resection was performed. Three lesions were removed gross totally in a piece-meal fashion. Following the surgical management, no postoperative complication occurred. Three patients underwent radiotherapy (RT. On an average follow-up of 6 years with clinical and MRI imaging, no recurrence was detected and symptoms of LBP and neurologic findings improved after 2 months.CONCLUSIONS: Primary multifocal MPE is an extremely rare event occurring in the conus medullaris or filum terminale. The exact pathogenesis of this condition is unclear. Multifocal MPE may be due to multifocal growth of tumors, early stage of growth of a giant tumor or drop metastasis of tumor in the subarachnoid space. En bloc resection or piecemeal resection with radiotherapy were associated with satisfactory outcome without recurrence.
机译：背景技术：硫杂虫血肿（MPE）是通常发生在康塞髓菌或粉末末端的难以发生的难题变体。通常是单一包膜病变。本研究的目的是描述菲尔姆底座母射线初级多焦点MPE的患者。在这项回顾性研究中，22例脊柱MPE患者的医疗记录在2003年1月至2010年1月期间接受了我院外手术治疗的患者。该研究包括14名男性和8名女性，年龄为11至66岁。有14名成人患者和8名儿科患者。临床介绍患者腰痛（LBP），放射性，局灶性神经缺陷和颅神经麻痹。结果：在FILUM底座上用初级多焦点MPE提出四种病例。所有这些都有慢性LBP至少2 - 3年。三名患者有下肢放射病变，患有尿失禁。在磁共振成像（MRI）上，3例患有两个病变的患者，一个患者在不同的脊柱水平下呈现三个病变（共9mPes）。所有病变均显示钆施用后钆施氮后的增强。对于6种肿瘤，en Bloc切除切除。三个病变完全以一顿饭方式除去总毛。在手术管理之后，没有发生术后并发症。三名患者接受放疗（RT.临床和MRI成像的平均随访6年，未经检测到复发，并且2个月后LBP和神经系统结果的症状改善。结论：主要多灶性MPE是一种非常罕见的事件Conus medullaris或Filum inalliente。这种情况的确切发病机制尚不清楚。多灶性MPE可能是由于肿瘤的多焦点生长，蛛网膜下腔空间中巨型肿瘤或肿瘤的肿瘤转移的早期阶段。ZHOC切除或零碎用放射疗法切除与令人满意的结果无关。

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