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首页> 外文期刊>Journal of neurotrauma >Neuroimmunology of Traumatic Brain Injury: A Longitudinal Study of Interdependency of Inflammatory Markers and Heart Rate Variability in Severe Traumatic Brain Injury
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Neuroimmunology of Traumatic Brain Injury: A Longitudinal Study of Interdependency of Inflammatory Markers and Heart Rate Variability in Severe Traumatic Brain Injury

机译：创伤性脑损伤的神经免疫学：严重创伤性脑损伤中炎症标志物相互依存性的纵向研究

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摘要

The aim of the present study is to evaluate the interdependency between heart rate variability (HRV) and inflammatory markers in patients with severe traumatic brain injury (TBI). A prospective exploratory study was done with a sample size of 89 patients. HRV of these patients was recorded using a telemetric device. The recordings were made on day 1 of the patients' admission into the intensive care unit followed by serial recordings on day 3 and day 10. Serum samples of the patients were also collected on these days for analysis of interleukin (IL)-1, IL-6, IL-10, and tumor necrosis factor alpha levels using enzyme-linked immunosorbent assay kits. The outcome assessment was done using the Disability Rating Scale at discharge and Glasgow Outcome Scale-Extended at 6 months post-trauma. The data were analyzed by grouping the patients on based on mortality and outcome. In the present study, there was significant subclinical autonomic dysfunction in patients with severe TBI. Among the serum cytokines, levels of IL-10 had a significant impact on outcome. An increase in IL-10 levels correlated with the unfavorable outcome. This study highlights the association between the HRV parameters and immune response. The timely management of both autonomic and immune dysfunction in patients with severe TBI may have an impact in preventing the secondary injury process.
机译：本研究的目的是评估心率变异性（HRV）（HRV）和炎症性脑损伤患者（TBI）的炎症标志物之间的相互依赖性。使用89名患者的样本大小进行了一个预期探索性研究。使用遥测装置记录这些患者的HRV。录音是在第1天的患者入院中进行的，然后在第3天和第10天序列记录。在这些天中也收集患者的血清样本，以分析白细胞介素（IL）-1，IL使用酶联免疫吸附试剂盒-6，IL-10和肿瘤坏死因子α水平。结果评估是使用残疾评级规模在出院时的排放量和Glasgow成果延长延长后创伤后的6个月。通过基于死亡率和结果对患者进行分析来分析数据。在本研究中，严重TBI患者存在显着的亚临床自主神经功能障碍。在血清细胞因子中，IL-10的水平对结果产生了重大影响。 IL-10水平的增加与不利结果相关。本研究突出了HRV参数和免疫应答之间的关联。及时管理严重TBI患者的自主主义和免疫功能障碍可能对预防二次伤害过程产生影响。

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