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首页> 外文期刊>Journal of neuroendocrinology >Menopause is associated with decreased postprandial ghrelin, whereas a history of anorexia nervosa is associated with increased total ghrelin
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Menopause is associated with decreased postprandial ghrelin, whereas a history of anorexia nervosa is associated with increased total ghrelin

机译：更年期与晚期Ghrelin减少有关，而厌食症的历史与增加的Ghrelin总有关

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Middle age has been linked with various dysfunctional eating patterns in women. The hormone ghrelin is related to food intake, with plasma levels rising before eating and decreasing immediately afterwards. Animal research has shown that oestradiol is an antagonist of ghrelin. Given that both menopause and anorexia nervosa ( AN ) are states characterised by reduced oestradiol, the present study aimed to investigate for the first time whether menopausal status and a history of AN are linked with altered ghrelin levels in middle‐aged women. Based on previous research, we hypothesised that (i) post‐menopausal women would demonstrate comparably increased ghrelin after food intake and (ii) women with a history of AN would exhibit increased total ghrelin levels. Healthy, middle‐aged women (n?=?57) were recruited. Of the women, 31 were post‐menopausal and 27 had a history of AN . Plasma ghrelin was repeatedly collected before and after a meal standardised in terms of caloric content. Areas under the curves were calculated to indicate total ( AUC g) and postprandial ghrelin ( AUC i). Menopausal status was linked with postprandial ghrelin ( AUC i ?1.6?±?2.2 vs ?2.9?±?2.6; P ?=?0.058), whereas a history of AN was linked with total ghrelin ( AUC g 36.2?±?5.6 vs 39.0?±?3.7; P ?=?0.050). There were no interaction effects (both P??0.466). A closer examination of the effects revealed that post‐menopausal women showed marginally greater decreases in ghrelin immediately after food intake ( P ?=?0.064) and marginally greater re‐increases after 60?minutes ( P ?=?0.084) compared to pre‐menopausal women. Women with a history of AN had significantly higher total ghrelin compared to women without a history of AN ( P ?=?0.042). Post‐menopause was linked with higher sensitivity of ghrelin to food intake (trend), whereas a history of AN was related to greater total ghrelin. Future research should investigate to what extent the observed alterations in ghrelin may affect dysfunctional eating behaviour during middle age.
机译：中年已与女性的各种功能失调饮食模式有关。激素Ghrelin与食物摄入有关，等离子体水平在进食前升高并立即降低。动物研究表明，Ostradiol是Ghrelin的拮抗剂。鉴于更年期和厌食症神经症（AN）是由雌二醇还原的州，目前的研究旨在首次调查日期血症状态和历史是否与中年妇女的改变的Ghrelin水平相关联。基于以前的研究，我们假设（i）绝经后妇女将在食物摄入后的妇女在患有历史上表现出较高的Ghrelin水平的妇女进行比较增加的Ghrelin。招募了健康的中年女性（N？=？57）。女性，31岁是绝经后，27个有一个历史。在卡路里含量标准化之前和之后，反复收集血浆Ghrelin。计算曲线下的区域以表明总（AUC G）和餐后GHRELIN（AUC I）。更年期的状态与餐后Ghrelin相关联（AUC I？1.6？±2.2 vs？2.9？2.9？2.6; p？= 0.058），而历史与总Ghrelin（Auc G 36.2？±5.6 vs）相关联39.0？±3.7; p？=？0.050）。没有相互作用效应（P？＆Δ0.466）。对效果的仔细检查显示，在食物摄入后，绝经后妇女在GHRELIN中表现得略微更大（P？= 0.064），并且在60？分钟后的重新增加（P？= 0.084）比较绝经妇女。与没有历史的女性相比，患有历史的妇女与没有历史的女性（p？= 0.042）。绝经后与Ghrelin对食物摄入量的敏感性相连（趋势），而A的历史与更大的Ghrelin有关。未来的研究应调查在中年期间Ghrelin中观察到的改变可能会影响功能障碍饮食行为的程度。

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