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首页> 外文期刊>Journal of neuroendocrinology >Glucose availability regulates ghrelin‐induced food intake in the ventral tegmental area
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Glucose availability regulates ghrelin‐induced food intake in the ventral tegmental area

机译：葡萄糖可用性调节腹侧区域区域的Ghrelin诱导的食物摄入量

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Information about metabolic status arrives in the brain in the form of a complex milieu of circulating signalling factors, including glucose and fatty acids, ghrelin, leptin and insulin. The specific interactions between humoural factors, brain sites of action and how they influence behaviour are largely unknown. We have previously observed interactions between glucose availability and the actions of ghrelin mediated via the agouti‐related peptide neurones of the hypothalamus. In the present study, we examine whether these effects generalise to another ghrelin‐sensitive brain nucleus, the ventral tegmental area ( VTA ). We altered glucose availability by injecting mice with glucose or 2‐deoxyglucose i.p. to induce hyperglycaemia and glucopenia, respectively. Thirty minutes later, we injected ghrelin in the VTA . Glucose administration suppressed intra‐ VTA ghrelin‐induced feeding. Leptin, a longer‐term signal of positive energy balance, did not affect intra‐ VTA ghrelin‐induced feeding. 2‐Deoxyglucose and ghrelin both increased food intake in their own right and, together, they additively increased feeding. These results add support to the idea that calculation of metabolic need depends on multiple signals across multiple brain regions and identifies that VTA circuits are sensitive to the integration of signals reflecting internal homeostatic state and influencing food intake.
机译：有关代谢状态的信息以循环信号传导因子的复杂环境形式到达大脑，包括葡萄糖和脂肪酸，Ghrelin，瘦素和胰岛素。肱骨因子，脑部的行动脑部位与影响行为的特异性相互作用在很大程度上是未知数。我们之前观察到葡萄糖可用性与Ghrelin之间的相互作用，并通过丘脑刺激的刺槐肽神经元介导的Ghrelin。在本研究中，我们检查这些效果是否推广到另一个Ghrelin敏感的脑核，腹侧腹侧区域（VTA）。通过用葡萄糖或2-脱氧葡萄糖I.P注入小鼠，我们改变了葡萄糖可用性。分别诱发高血糖和葡糖钙症。三十分钟后，我们在VTA中注射了Ghrelin。葡萄糖给药抑制了VTA内诱导的饲料。瘦素是阳性能量平衡的长期信号，不影响VTA内诱导的喂养。 2-脱氧葡萄糖和Ghrelin在他们自己的权利中增加食物摄入量，在一起，它们会增加饲养。这些结果为思想提供了支持，即代谢需求的计算取决于多个脑区域的多个信号，并识别VTA电路对反映内部稳态和影响食物摄入的信号的集成敏感。

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