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首页> 外文期刊>Journal of neuroendocrinology >Alternation between short‐ and long photoperiod reveals hypothalamic gene regulation linked to seasonal body weight changes in Djungarian hamsters ( Phodopus sungorus Phodopus sungorus )
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Alternation between short‐ and long photoperiod reveals hypothalamic gene regulation linked to seasonal body weight changes in Djungarian hamsters ( Phodopus sungorus Phodopus sungorus )

机译：短期和长光周期之间的交替揭示了Djungarian Hamsters（Phodopus Sungopus Sungorus）的季节性体重变化相关的下丘脑基因调节

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Djungarian hamsters are able to reduce their body weight by more than 30% in anticipation of the winter season. This particular adaptation to extreme environmental conditions is primarily driven by a natural reduction in day length and conserved under laboratory conditions. We used this animal model to investigate hypothalamic gene expression linked to body weight regulation behind this physiological phenomenon. After an initial collective short photoperiod ( SP ) adaptation for 14?weeks from a preceding long photoperiod ( LP ), hamsters were re‐exposed to LP for either 6 or 14?weeks, followed by a second re‐exposure to SP for 8?weeks. Our data showed that re‐exposure to LP led to an increase in body weight. In the hypothalamus Dio2 , Vimentin , Crbp1 and Grp50 expression increased, whereas expression of Dio3 , Mct8 and Srif decreased. The changes in body weight and gene expression were reversible in most hamsters after a further re‐exposure to SP following 6 or 14?weeks in LP . Interestingly, after 14 weeks in LP , body weight loss was pronounced in six hamsters re‐exposed to SP , but five hamsters did not respond. In nonresponding hamsters, a different gene expression pattern was manifested, with the exception of Dio2 , which was reduced not only in SP re‐exposed hamsters, but also in hamsters maintained in LP . Taken together, these data suggest that body weight regulation appears to be tightly linked to a co‐ordinated regulation of several genes in the hypothalamus, including those involved in thyroid hormone metabolism.
机译：Djungarian Hamsters能够以预期冬季的预期减少30％以上的体重。这种特殊适应极端环境条件主要由日期长度的自然减少和在实验室条件下保守。我们使用这种动物模型来研究与这种生理现象背后的体重调节相关的下丘脑基因表达。在初始集体短的光周期（SP）适应14〜60周后，从前面的长光（LP），仓鼠被重新暴露于6或14个周的LP？周，然后将第二次重新暴露于SP，为8？周。我们的数据表明，重新接触LP导致体重增加。在下丘脑DIO2中，Vimentin，CRBP1和GRP50表达增加，而DIO3，MCT8和SRIF的表达降低。在进一步再暴露于6或14周后，大多数仓鼠在大多数仓鼠中，体重和基因表达的变化是可逆的。有趣的是，在LP 14周后，体重减轻在六个仓鼠被重新接触到SP，但五只仓鼠没有回应。在非反应的仓鼠中，表现出不同的基因表达模式，除了DIO2之外，不仅在SP重新暴露的仓鼠中减少，而且还在LP维持的仓鼠中减少。总之，这些数据表明体重调节似乎与下丘脑中几种基因的协调调节紧密相关，包括参与甲状腺激素代谢的人。

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