...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of neuroendocrinology >Alteration in intrinsic and extrinsic functional connectivity of resting state networks associated with subclinical hypothyroidism
【24h】

Alteration in intrinsic and extrinsic functional connectivity of resting state networks associated with subclinical hypothyroidism

机译：与亚临床甲状腺功能减退症相关的静态状态网络的内在和外在功能连通性的改变

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Subclinical hypothyroidism (SCH) is characterised by a mild elevation of thyroid-stimulating hormone (range 5-10 mu lU mL(-1)) and normal free triiodothyronine and free thyroxine. Cognitive function impairment is well known in thyroid disorders such as hypothyroidism and hyperthyroidism, although little is known about deficits in brain functions in SCH subjects. Also, whether hormone-replacement treatment is necessary or not in SCH subjects is still debatable. To obtain an insight into the cognition of SCH subjects, intrinsic and extrinsic functional connectivity (FC) of the resting state networks (RSNs) was investigated. For resting state data analysis, we used an unbiased, data-driven approach based on independent component analysis and dual-regression, which can emphasise widespread changes in FC without restricting to a set of predefined seeds. In total, 28 SCH subjects and 28 matched healthy controls (HCs) participated in the study. RSN analysis showed significantly decreased intrinsic FC in somato-motor network (SMN) and right frontoparietal attention network (RAN) and increased intrinsic FC in default mode network (DMN) in SCH subjects compared to control subjects. The reduced intrinsic FC in the SMN and RAN suggests neurocognitive alterations in SCH subjects in the corresponding functions, as also evident from the deficit in the neuropsychological performance of the SCH subjects on behavioural tests, such as digit span, delayed recall, visual retention, recognition, Bender Gestalt and Mini-Mental State Examination. We also found a significant reduction in extrinsic network FC between DMN and RAN; SMN and posterior default mode network; and increased extrinsic FC between SMN and anterior default mode network in SCH subjects compared to controls. An altered extrinsic FC in SCH suggests functional reorganisation in response to neurological disruption. The partial correlation analysis between intrinsic and extrinsic RSN FC and neuropsychological performances, as well as clinical indices, provides interesting insights into the brain-behaviour relationship in SCH subjects.
机译：亚临床甲状腺功能减退症（SCH）的特征在于甲状腺刺激激素的轻度升高（范围5-10μlul（-1））和正常的三碘甲羟基酮和游离甲状腺素。认知函数损伤是甲状腺功能亢进症，如甲状腺功能减退症和甲状腺功能亢进，尽管在SCH受试者中脑功能缺陷几乎是知之甚少。此外，是否必须在SCH受试者中必要或不替代激素替代治疗。为了获得对SCH受试者的认知的洞察，研究了静置状态网络（RSNS）的内在和外在功能连接（FC）。为了休息状态分析，我们使用基于独立分量分析和双回归的无偏见，数据驱动方法，这可以强调FC的广泛变化而不限制一组预定义种子。总共28个SCH受试者和28种匹配的健康控制（HCS）参与了该研究。 RSN分析显示，与对照科目相比，SOMOT-MOTER网络（SMN）和右前期注意网络（RAN）和右前期关注网络（RAN）和默认模式网络（DMN）中的内在FC增加。 SMN和RAN中降低的内在Fc表明SCH受试者中的神经认知改变在相应的功能中，从SCH受试者对行为测试的神经心理学性能的缺陷中也明显明显，例如数字跨度，延迟召回，视觉保留，识别，弯曲的甲般的恐怖和迷你精神状态检查。我们还发现DMN和RAN之间的外部网络FC显着减少; SMN和后默默认模式网络;与控制相比，SCH受试者中SMN和前默认模式网络之间的外部FC增加。 SCH中改变的外部FC表明响应神经系统破坏的功能重组。内在和外在RSN Fc和神经心理表演的部分相关性分析以及临床指标，为SCH受试者中的大脑行为关系提供了有趣的见解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号