Activation of the rat hypothalamic supramammillary nucleus by food anticipation, food restriction or ghrelin administration

Le May Marie V.; Hume Catherine; Sabatier Nancy; Schéle Erik; Bake Tina; Bergstr?m Ulrika; Menzies John; Dickson Suzanne L.

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Activation of the rat hypothalamic supramammillary nucleus by food anticipation, food restriction or ghrelin administration

机译：食品预期，食物限制或Ghrelin施用对大鼠下丘脑氨丙胺核的激活

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The circulating orexigenic hormone ghrelin targets many brain areas involved in feeding control and signals via a dedicated receptor, the growth hormone secretagogue receptor 1A. One unexplored target area for ghrelin is the supramammillary nucleus (SuM), a hypothalamic area involved in motivation and reinforcement and also recently linked to metabolic control. Given that ghrelin binds to the SuM, we explored whether SuM cells respond to ghrelin and/or are activated when endogenous ghrelin levels are elevated. We found that peripheral ghrelin injection activates SuM cells in rats, reflected by an increase in the number of cells expressing c‐Fos protein in this area, as welll as by the predominantly excitatory response of single SuM cells recorded in in vivo electrophysiological studies. Further c‐Fos mapping studies reveal that this area is also activated in rats in situations when circulating ghrelin levels are known to be elevated: in food‐restricted rats anticipating the consumption of food and in fed rats anticipating the consumption of an energy‐dense food. We also show that intra‐SuM injection of ghrelin induces a feeding response in rats suggesting that, if peripheral ghrelin is able to access the SuM, it may have direct effects on this brain region. Collectively, our data demonstrate that the SuM is activated when peripheral ghrelin levels are high, further supporting the emerging role for this brain area in metabolic and feeding control.

机译：循环的orexigenic激素Ghrelin靶向许多通过专用受体，生长激素分泌抑制因子1a参与喂养控制和信号的大脑区域。 Ghrelin的一个未开发的目标区域是Supramillary核（SUM），该区域涉及动机和增强以及最近与代谢控制相关联。鉴于Ghrelin与总和结合，我们探讨了uk细胞是否响应Ghrelin和/或在内源Ghrelin水平升高时激活。我们发现外周Ghrelin注射激活大鼠中的和细胞，通过在该区域中表达C-FOS蛋白的细胞数量的增加而反映，如在体内电生理学研究中记录的单总和细胞的主要兴奋性反应一样。进一步的C-FOS映射研究表明，当已知循环Ghrelin水平时，该区域也在大鼠中被激活：在食物限制大鼠中，预期食物的消耗和喂食大鼠预期能量密集的食物消耗。我们还表明，GHRELIN的血管内注射液诱导大鼠的饲养反应，提示，如果外周GHRELIN能够获得该总和，则可能对该脑区域具有直接影响。集体，我们的数据表明，当外周Ghrelin水平高时，总和是激活的，进一步支持代谢和喂养控制中该脑区域的新兴作用。

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《Journal of neuroendocrinology》 |2019年第7期|共14页
作者
Le May Marie V.; Hume Catherine; Sabatier Nancy; Schéle Erik; Bake Tina; Bergstr?m Ulrika; Menzies John; Dickson Suzanne L.;
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作者单位

Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of;

Centre for Discovery Brain SciencesUniversity of EdinburghEdinburgh UK;

Centre for Discovery Brain SciencesUniversity of EdinburghEdinburgh UK;

Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of;

Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of;

Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of;

Centre for Discovery Brain SciencesUniversity of EdinburghEdinburgh UK;

Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of;

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正文语种 eng
中图分类神经病学;
关键词
feeding; food anticipation; ghrelin; hypothalamus; supramammillary nucleus;

机译：喂养;食物预期;Ghrelin;下丘脑;上丙胺核心;

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专利

1. Activation of the rat hypothalamic supramammillary nucleus by food anticipation, food restriction or ghrelin administration [J] . Le May Marie V., Hume Catherine, Sabatier Nancy, Journal of neuroendocrinology . 2019,第7期

机译：食品预期，食物限制或Ghrelin施用对大鼠下丘脑氨丙胺核的激活
2. Central ghrelin increases food foraging/hoarding that is blocked by GHSR antagonism and attenuates hypothalamic paraventricular nucleus neuronal activation [J] . Michael A. Thomas, Vitaly Ryu, Timothy J. Bartness American Journal of Physiology . 2016,第2aPta2期

机译：中央Ghrelin增加了由GHSR拮抗作用阻止的食品觅食/囤积，并衰减下丘脑椎间盘内核神经元激活
3. Food restriction alters neuronal morphology in the hypothalamic ventromedial nucleus of male rats. [J] . Flanagan-Cato LM, Fluharty SJ, Weinreb EB, Endocrinology . 2008,第1期

机译：食物限制会改变雄性大鼠下丘脑腹膜外核的神经元形态。
4. Food-borne Diseases: Situation of Diarrheal Diseases in Thailand: Food Control Division, Food and Drug Administration, Thailand [C] . anonymous Food and Agriculture Organization of the United Nations/World Hearlth Organization Rgional Conference on Food Safety for Asia and the Pacific . 2004

机译：食品传播疾病：泰国腹泻病的情况：泰国食品管制部，食品和药物管理局
5. Dorsomedial Hypothalamic Prodynorphin Neuron Is Crucial for Expression of Food Anticipation in Mice [D] . Kuo, Tzu-wei. 2019

机译：背体下丘脑Prodynorphin神经元对于表达小鼠的食物预期至关重要
6. Central ghrelin increases food foraging/hoarding that is blocked by GHSR antagonism and attenuates hypothalamic paraventricular nucleus neuronal activation [O] . Michael A. Thomas, Vitaly Ryu, Timothy J. Bartness -1

机译：中心生长素释放肽增加了被GHSR拮抗作用阻止的食物觅食/ ho积并减弱了下丘脑室旁核的神经元活化
7. Intracerebroventricular Administration of Metformin Inhibits Ghrelin-Induced Hypothalamic AMP-Kinase Signalling and Food Intake [O] . Vladimir Trajkovic B, Metformin [(-(diaminomethylidene)- -dimethyl 2015

机译：侧脑室注射二甲双胍可抑制生长素释放肽诱导的下丘脑amp-激酶信号传导和食物摄入

Activation of the rat hypothalamic supramammillary nucleus by food anticipation, food restriction or ghrelin administration

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