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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >VEGF and mRNA VEGF expression in CSF from Behcet's disease with neurological involvement.
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VEGF and mRNA VEGF expression in CSF from Behcet's disease with neurological involvement.

机译：VEGF和MRNA VEGF在CSF中的表达来自Behcet的疾病，神经疾病。

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Vascular endothelial growth factor (VEGF) stimulates angiogenesis, but is also pro-inflammatory and plays an important role in the development of neurological disease, where it can have both attenuating and exacerbating effects. Several studies have indicated that VEGF-A (VEGF) may play a role in the pathogenesis of neurological inflammatory diseases. To assess the role of VEGF in patients with Behcet's disease with neurological involvement, VEGF was measured in the cerebrospinal fluid (CSF) of 32 patients compared to a group of 12 patients with noninflammatory neurological diseases (NIND) and 14 patients with multiple sclerosis (MS). We have also studied the expression of mRNA-VEGF (VEGF-A) in CSF and in peripheral blood mononuclear cells. The mean VEGF(CSF) was significantly increased in neuro-BD and MS patients compared to NIND patients. There was an association between neuro-BD-VEGF(CSF), and leukocyte count. A significant correlation was also observed between neuro-BD-VEGF(CSF) and CSF(%CD4) cells. As a measure of the integrity of the blood-brain barrier Q(albumin) was found correlated to VEGF(CSF). VEGF mRNA was significantly increased in neuro-BD patients compared to NIND patients. These results indicate that, VEGF may be associated with the increased percentages of CD4 cell subpopulation. The role of VEGF is within the inflammatory cascade in the mediation of blood-brain barrier disruption and not specific to Behcet's.
机译：血管内皮生长因子（VEGF）刺激血管生成，但也是促炎症，在神经疾病的发展中起重要作用，在那里它可以具有衰减和恶化的效果。几项研究表明，VEGF-A（VEGF）可能在神经炎症疾病的发病机制中发挥作用。为了评估VEGF在患有神经疾病患者的患者中的角色，与32例患者的脑脊液（CSF）测量VEGF，与一组12名非炎症神经系统疾病（NIND）和14名多发性硬化患者（MS ）。我们还研究了CSF和外周血单核细胞中mRNA-VEGF（VEGF-A）的表达。与NIND患者相比，神经BD和MS患者的平均VEGF（CSF）显着增加。 Neuro-BD-VEGF（CSF）和白细胞计数之间存在关联。在神经-BD-VEGF（CSF）和CSF（％CD4）细胞之间也观察到显着的相关性。发现血脑屏障Q（白蛋白）的完整性与VEGF（CSF）相关。与NIND患者相比，在神经BD患者中，VEGF mRNA显着增加。这些结果表明，VEGF可能与CD4细胞亚群的百分比增加相关。 VEGF的作用在血脑屏障中断的中介中的炎症级联中，而不是特定于Behcet的。

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