The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis.

OBrien K; Fitzgerald D; Rostami A; Gran B

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis.

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The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis.

机译：TLR7激动剂，咪喹莫特增加了IFN-Beta生产，并降低了实验性自身免疫性脑髓炎的严重程度。

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Experimental autoimmune encephalomyelitis (EAE) is a well-characterised model of autoimmune inflammatory demyelination. Toll-like receptors (TLRs) recognise microbial components and initiate innate immune responses. We report in this study that TLR7 stimulation by imiquimod, a synthetic analog of ssRNA, suppresses disease severity in a chronic EAE model. Disease suppression is associated with increased IFN-beta production in spleens of mice treated with imiquimod. In vitro experiments on pDCs, which express high levels of TLR7 and are potent producers of IFN-beta, suggest that an amplification loop involving TLR7 and IFNAR is required for the observed effects.

机译：实验性自身免疫性脑肌炎（EAE）是一种具有良好特征的自身免疫炎症脱髓鞘模型。 Toll样受体（TLRS）识别微生物组分并引发天生的免疫应答。我们在这项研究中报告，通过咪喹莫特（SSRNA合成类似物）的TLR7刺激抑制了慢性EAE模型中的疾病严重程度。疾病抑制与用氨基铵处理的小鼠脾脏的IFN-β产生增加有关。对PDC的体外实验，其表达高水平的TLR7并是IFN-Beta的有效生产者，表明观察到的效果需要涉及TLR7和IFNAR的放大回路。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2010年第2期|共5页
作者
OBrien K; Fitzgerald D; Rostami A; Gran B;
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作者单位

Division of Clinical Neurology University of Nottingham Nottingham United Kingdom.;

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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
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1. The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis. [J] . OBrien K, Fitzgerald D, Rostami A, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2010,第1a2期

机译：TLR7激动剂咪喹莫特可增加IFN-β的产生并降低实验性自身免疫性脑脊髓炎的严重程度。
2. The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis. [J] . OBrien K, Fitzgerald D, Rostami A, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2010,第1a2期

机译：TLR7激动剂，咪喹莫特增加了IFN-Beta生产，并降低了实验性自身免疫性脑髓炎的严重程度。
3. The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis. [J] . OBrien K, Fitzgerald D, Rostami A, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2010,第1a2期

机译：TLR7激动剂，咪喹莫特增加了IFN-Beta生产，并降低了实验性自身免疫性脑髓炎的严重程度。
4. Direct Current Electrical Enhanced Oil Recovery in Heavy-Oil Reservoirs to Improve Recovery, Reduce Water Cut, and Reduce H2S Production while Increasing API Gravity [C] . J. K. Wittle, D.G. Hill, G.V. Chilingar Society of Petroleum Engineers Western Regional and Pacific Section AAPG Joint Meeting . 2008

机译：直流电力增强耐油储层中的采油，以改善恢复，减少水切割，并减少H2S生产，同时增加API重力
5. Hormones and dendritic cells: Influences on the initiation of the autoimmune disease experimental autoimmune encephalomyelitis. [D] . Papenfuss, Tracey L. 2007

机译：激素和树突状细胞：对自身免疫性疾病实验性自身免疫性脑脊髓炎的发作的影响。
6. In vivo Administration of TLR9 Agonist Reduces the Severity of Experimental Autoimmune Encephalomyelitis. The Role of Plasmacytoid Dendritic Cells and B Lymphocytes [O] . Ana Leda F. Longhini, Mariana P. A. Santos, Fernando Pradella, 2014

机译：TLR9激动剂的体内给药可降低实验性自身免疫性脑脊髓炎的严重程度。浆细胞样树突状细胞和B淋巴细胞的作用
7. In vivoAdministration of TLR9 Agonist Reduces the Severity of Experimental Autoimmune Encephalomyelitis. The Role of Plasmacytoid Dendritic Cells and B Lymphocytes [O] . Ana Leda F. Longhini, Mariana P. A. Santos, Fernando Pradella, 2014

机译：在TLR9的vivoadmitoration中，激动剂可降低实验性自身免疫性脑髓炎的严重程度。血浆骨质特性细胞和B淋巴细胞的作用

The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis.

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