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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia.
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Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia.

机译:肌炎肌无力与胸腺淋巴增生的异位和高CXCL13趋化因子。

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摘要

Myasthenia gravis (MG) is an antibody and complement mediated autoimmune disease. Serum CXC chemokine ligand 13 (CXCL13) was found to be elevated in MG patients and high CXCL13 level was associated with severe clinical stages, especially in females with thymic lymphoid hyperplasia. Both protein and mRNA of CXCL13 and CXC chemokine receptor 5 (CXCR5) in the thymic tissues were significantly higher in MG patients with lymphoid hyperplasia than those with thymoma. Our data indicated that serum CXCL13 can be used as an index of disease severity and ectopic thymic expression of CXCL13 might be associated with aberrant cell trafficking to the thymus of MG.
机译:Myasthenia gravis(mg)是一种抗体和补体介导的自身免疫疾病。 发现血清CXC趋化因子配体13(CXCL13)在Mg患者中升高,高CXCL13水平与严重的临床阶段相关,特别是患有胸腺淋巴增生的雌性。 胸腺组织中的CXCL13和CXC趋化因子受体5(CXCR5)的蛋白质和MRNA在MG患者中显着高于淋巴增生而不是胸腺瘤。 我们的数据表明,血清CXCL13可用作疾病的分数,CXCL13的异位胸腺表达可能与异常胞间植物交付给MG的胸腺相关。

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