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首页> 外文期刊>Journal of natural medicines >Gastroprotective effect of palmatine against acetic acid-induced gastric ulcers in rats
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Gastroprotective effect of palmatine against acetic acid-induced gastric ulcers in rats

机译：棕榈啶对大鼠醋酸诱导胃溃疡的胃肠道反应效果

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摘要

Gastric ulcers are one of the most common gastrointestinal disorders. The aim of this study was to investigate the gastroprotective activity and possible underlying mechanisms of palmatine against acetic acid-induced gastric ulcers in rats. Palmatine was administered orally for 7 consecutive days to treat ulcers. The ulcer area, ulcer inhibition rate, histological section, platelet-activating factor (PAF) level in serum, prostaglandin E-2 (PGE(2)) level in gastric tissue, 5-hydroxytryptamine (5-HT) level in the brain and norepinephrine (NE) level in the adrenal glands were analyzed. Histological results showed that the ulcer areas were significantly decreased by both doses of palmatine (10 and 20 mg/kg/day) compared with the model group, and the ulcer inhibition rates were 51.42% and 60.92%, respectively. Palmatine treatment markedly increased the level of PGE(2) and decreased PAF, compared with the model group; however, it had no significant effect on 5-HT and NE levels. The results indicated that palmatine may exert a gastroprotective effect against gastric ulcers, and the mechanisms might be associated with the anti-inflammatory status and the protection of gastric mucosa via increasing PGE(2) and decreasing PAF rather than neurohumoral regulation through 5-HT and NE. Thus, palmatine is a potential drug for treatment of gastric ulcers.
机译：胃溃疡是最常见的胃肠道障碍之一。本研究的目的是探讨棕榈啶对醋酸诱导的大鼠胃溃疡的胃癌的胃癌活动和可能的潜在机制。棕榈丁在口服施用连续7天以治疗溃疡。溃疡面积，溃疡抑制率，组织学截面，血清中的血清，前列腺素E-2（PGE（2））水平在胃组织中，脑中的5-羟基--T胺（5-HT）水平和血清分析了肾上腺中的去甲肾上腺素（NE）水平。组织学结果表明，与模型组相比，溃疡面积（10和20mg / kg /天）显着降低，溃疡抑制率分别为51.42％和60.92％。与模型组相比，棕榈泥治疗显着增加了PGE（2）和PAF减少的水平;但是，它对5-HT和NE水平没有显着影响。结果表明，棕榈丁可以对胃溃疡产生胃保护作用，并且机制可能与抗炎状态和通过增加PGE（2）和通过5-HT降低的PAF而不是神经胃部调节的抗炎状态和保护胃粘膜。 NE。因此，棕榈泥是一种用于治疗胃溃疡的潜在药物。

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  • 来源
    《Journal of natural medicines》 |2017年第1期|共8页
  • 作者

    Wang Ling; Wang Xue; Zhang Su-Li; Zhu Xiao-Ming; Liu Yan-Qi; Song Zi-Jing; Du Wen-Juan; Ji Jun; Cui Cheng-Long; He Xin; Zhang Chun-Feng; Guo Chang-Run; Wang Chong-Zhi; Yuan Chun-Su;

  • 作者单位

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    Nanjing Univ Chinese Med Sch Pharm Nanjing 210000 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    Univ Chicago Dept Anesthesia &

    Crit Care Tang Ctr Herbal Med Res Box 428 Chicago IL 60637 USA;

    Univ Chicago Dept Anesthesia &

    Crit Care Tang Ctr Herbal Med Res Box 428 Chicago IL 60637 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    Palmatine; Gastroprotective action; Acetic acid-induced gastric ulcer; Anti-inflammation;

    机译：棕榈泥;胃肠保护作用;醋酸诱导的胃溃疡;抗炎;

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