...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Matrix metalloproteases-responsive nanomaterials for tumor targeting diagnosis and treatment
【24h】

Matrix metalloproteases-responsive nanomaterials for tumor targeting diagnosis and treatment

机译：肿瘤靶向诊断和治疗的基质金属蛋白酶响应纳米材料

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tumour poses tremendous challenges to mankind. In various tumours, matrix metalloproteases (MMPs) are ubiquitously over expressed and participate throughout the process of tumour development. MMPs are commonly used as internal stimuli, and MMPs-responsive nanomaterials are classified into three categories according to the drug delivery process: administration and distribution to tumour, intratumoural distribution and cell internalisation, and specific drug release. First, MMPs-sensitive polyethylene glycol (PEG) de-shielding and activatable cell penetrating peptides were developed to improve the blood circulation time of drug delivery systems, thereby, enhancing tumour or stroma cells recognition and penetration. Following tumour recognition, the MMPs-sensitive and size- or morphology-changeable nanoparticles (NPs) could highly accumulate and penetrate into tumour. Lastly, several MMPs-sensitive drug release strategies were feasible for both small molecule drugs and macromolecule drugs. In conclusion, recent novel advances of MMPs-responsive nanomaterials in tumour targeting diagnosis and treatment were highlighted in this review.
机译：肿瘤对人类带来了巨大的挑战。在各种肿瘤中，基质金属蛋白酶（MMPs）普遍存在于肿瘤发育过程中的表达和参与。 MMP通常用作内部刺激，并根据药物递送过程将MMPS响应的纳米材料分为三类：给予肿瘤，肿瘤瘤分布和细胞内化以及特定药物释放的给药和分配。首先，开发了MMPS敏感的聚乙二醇（PEG）去屏蔽和可活化细胞穿透肽，以改善药物递送系统的血液循环时间，从而提高肿瘤或基质细胞识别和渗透。在肿瘤识别之后，MMP敏感和尺寸或形态变化的纳米颗粒（NPS）可以高度积累并渗透到肿瘤中。最后，对于小分子药物和大分子药物，几种MMPS敏感的药物释放策略是可行的。总之，突出了肿瘤靶向诊断和治疗中MMPS响应纳米材料的最近新推进。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号