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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >In vitro evaluation of alpha-lipoic acid-loaded lipid nanocapsules for topical delivery
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In vitro evaluation of alpha-lipoic acid-loaded lipid nanocapsules for topical delivery

机译：α-硫辛酸负载脂纳米胶囊的体外评价进行局部输送

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摘要

This study aimed at in vitro evaluation of alpha-lipoic acid-loaded lipid nanocapsules for topical delivery, which was prepared by hot high-pressure homogenisation. Stable particles could be formed and particle size was 148.54 +/- 2.31 nm with polydispersity index below 0.15. Encapsulation efficiency and drug loading of alpha-lipoic acid were 95.23 +/- 0.45% and 2.81 +/- 0.37%. Antioxidant study showed alpha-lipoic acid could be protected by lipid nanocapsules without loss of antioxidant activity. Sustained release of alpha-lipoic acid from lipid nanocapsules was obtained and cumulative release was 62.18 +/- 1.51%. In vitro percutaneous study showed the amount of alpha-lipoic acid distributed in skin was 1.7-fold than permeated. Cytotoxicity assay and antioxidant activity on L929 cells indicated this formulation had low cytotoxicity and ability of protecting cells from oxidative damage within specific concentration. These studies suggested alpha-lipoic acid-loaded lipid nanocapsules could be potential formulation for topical delivery.
机译：该研究旨在对α-脂质酸负载的脂质纳米粉质进行局部递送的体外评价，其通过热高压均匀化制备。可以形成稳定的颗粒，并且粒度为148.54 +/- 2.31nm，多分散指数低于0.15。 α-硫辛酸的封装效率和药物负载为95.23 +/- 0.45％和2.81 +/- 0.37％。抗氧化研究显示α-硫辛酸可以通过脂质纳米腐植物保护而不丧失抗氧化活性。获得来自脂质纳米胶囊的α-脂质酸的持续释放，累积释放为62.18 +/- 1.51％。体外经皮的研究表明，在皮肤中分布的α-脂质酸的量比渗透为1.7倍。细胞毒性测定和L929细胞上的抗氧化活性表明，该配方具有低细胞毒性和保护细胞免受特定浓度内氧化损伤的能力。这些研究表明，α-硫辛酸负载的脂纳米胶囊可以是用于局部递送的潜在配方。

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