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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Systematic development of design of experiments (DoE) optimised self-microemulsifying drug delivery system of Zotepine
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Systematic development of design of experiments (DoE) optimised self-microemulsifying drug delivery system of Zotepine

机译：实验设计的系统发展（DOE）优化的Zotepine自微乳化药物递送系统

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摘要

The aim of present investigation is to improve dissolution rate of poor soluble drug Zotepine by a self-microemulsifying drug delivery system (SMEDDS). Ternary phase diagram with oil (Oleic acid), surfactant (Tween 80) and co-surfactant (PEG 400) at apex were used to identify the efficient self-microemulsifying region. Box-Behnken design was implemented to study the influence of independent variables. Principal Component Analysis was used for scrutinising critical variables. The liquid SMEDDS were characterised for macroscopic evaluation, % Transmission, emulsification time and in vitro drug release studies. Optimised formulation OL1 was converted in to S-SMEDDS by using Aerosil (R) VR 200 as an adsorbent in the ratio of 3:1. The S-SMEDDS was characterised by SEM, DSC, globule size (152.1 nm), zeta-potential (-28.1 mV), % transmission study (98.75%), in vitro release (86.57%) at 30 min. The optimised solid SMEDDS formulation showed faster drug release properties as compared to conventional tablet of Zotepine.
机译：目前调查的目的是通过自微乳化药物递送系统（SMEDDS）来改善可怜的可溶性药物Zotepine的溶出速率。用油（油酸），表面活性剂（TWEEN 80）和在顶点处的三元相图用于鉴定有效的自微乳化区域。开箱设计是实施的，以研究独立变量的影响。主要成分分析用于仔细临界临界变量。液体中小型的特征在于宏观评价，％透射，乳化时间和体外药物释放研究。通过使用AerosilVR200作为吸附剂的比例为3：1的吸附剂，优化的制剂OL1转化为S-SMEDDS。 S-SMEDDS的特征在于SEM，DSC，球状尺寸（152.1nm），Zeta-posity（-28.1mV），％透射研究（98.75％），体外释放（86.57％），在30分钟内。与常规的Zotepine片剂相比，优化的固体Smedds制剂显示出更快的药物释放性能。

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