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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Folate-decorated and NIR-activated nanoparticles based on platinum(IV) prodrugs for targeted therapy of ovarian cancer
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Folate-decorated and NIR-activated nanoparticles based on platinum(IV) prodrugs for targeted therapy of ovarian cancer

机译：基于铂（IV）前药的叶酸装饰和NIR激活的纳米颗粒，用于卵巢癌的靶向治疗

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摘要

Platinum-based drugs are used to treat a variety of cancers but have many side effects such as nephrotoxicity and neurotoxicity. A folate-decorated nanoparticles system with a good drug payload can selectively deliver drugs into folate receptor (FR)-overexpressing cancer cells to prevent the shortcomings of platinum-based chemotherapy. Here, folate-decorated and near-infrared (NIR) laser-activated nanoparticles (abbreviated as Pt-IV-FINPs) were prepared via ultrasonic self-assembling of platinum(IV) prodrug c,c,t-Pt(NH3)(2)Cl-2(OOCCH2CH2COOH)(2), folic acid (FA)-functionalized lipid DSPE-PEG-FA and NIR fluorescent dye indocyanine green (ICG). The obtained Pt-IV-FINPs had almost spherical shape with a mean diameter about 100 nm. In vitro cellular uptake, cytotoxicity assays revealed that upon NIR irradiation, Pt-IV-FINPs further enhanced cellular uptake and generated higher cytotoxicity against human ovarian carcinoma SKOV3 cells than non-targeted or non-NIR activated nanoparticles. Thus, the multifunctional nanoparticles have potential to be developed as an attractive drug delivery system for effective chemotherapy against FR-overexpressing cells.
机译：基于铂类药物用于治疗各种癌症，但具有许多副作用，如肾毒性和神经毒性。具有良好药物有效载荷的叶酸型纳米粒子系统可以选择性地将药物递送到叶酸受体（FR）中 - 过曲调癌细胞，以防止基于铂的化疗的缺点。这里，通过铂（IV）前药C，C，T-Pt（NH3）的超声自组装制备叶酸装饰和近红外（NIR）激光活化的纳米颗粒（缩写为PT-IV-FINP）（2 ）C1-2（OOCCH 2 CH 2 COOH）（2），叶酸（FA） - 官能化脂质DSPE-PEG-FA和NIR荧光染料吲哚菁绿（ICG）。所得PT-IV-FINP具有几乎具有平均直径约100nm的球形形状。在体外细胞摄取，细胞毒性测定显示，在NIR辐射时，PT-IV-FINP进一步增强了细胞摄取，并产生了比非靶向或非鼻炎的人卵巢癌SKOV3细胞产生更高的细胞毒性。因此，多官能纳米颗粒具有潜力作为有效的药物递送系统，用于针对FR过度抑制细胞的有效化学疗法。

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