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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Effect of solid lipid's structure on nanostructured lipid carriers encapsulated with sun filter: characterisation, photo-stability and in vitro release
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Effect of solid lipid's structure on nanostructured lipid carriers encapsulated with sun filter: characterisation, photo-stability and in vitro release

机译：固体脂质结构对纳米结构脂质携带者的影响，粉末过滤器：表征，光稳定性和体外释放

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摘要

Three series of solid lipid are formulated in nanostructured lipid carriers (NLC) system, which encapsulated with sun filter to evaluate the effect on the physicochemical properties of the nanocarriers. Production is performed by ultrasonication-homogenisation, analysis by particle size, zeta potential (ZP), transmission electron microscope, Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC), X-ray diffraction (XRD). Moreover, the encapsulation efficiency, ultraviolet performance and in vitro release are also investigated. The particle sizes of NLCs are between 185 and 225nm and the polydispersity index is lower than 0.4, ZP from -56.4 to -78.6mV, and the particles are spherical and in homogenous shading. All prepared NCLs encapsulated the sun filter and the EE are higher than 73%. DSC analysis revealed - to -polymorphic modification existed in the system of fatty alcohol and fatty acid. However, , and -polymorphic modifications are exist in the system of cetyl palmitate (PC). Compared with conventional emulsion, all NLCs displayed perfect photo-protective property, especially for the alcohol system. The photo-stability studies showed that the all NLCs have the ability to improve the photo-stability of sunscreens. The in vitro release study suggested all three NLCs displayed sustained release profile and they were fit well with Higuchi equation.
机译：三系列固体脂质在纳米结构脂质载体（NLC）系统中配制，其包封有太阳滤器，以评估对纳米载体的物理化学性质的影响。生产是通过超声均匀化进行的，通过粒度分析，Zeta电位（ZP），透射电子显微镜，傅里叶变换红外光谱，差示扫描量热法（DSC），X射线衍射（XRD）。此外，还研究了封装效率，紫外线性能和体外释放。 NLC的粒径在185和225nm之间，并且多分散指数低于0.4，ZP，ZP为-56.4至-78.6mV，颗粒是球形的，均匀的遮阳。所有制备的NCLS封装过阳过滤器，EE高于73％。 DSC分析显示 - 在脂肪醇和脂肪酸系统中存在 - 染色改性。然而，在十六烷棕榈酸酯（PC）的系统中存在和 - 聚合物修饰。与常规乳液相比，所有NLC都显示出完美的光保护性，特别是对于酒精系统。光稳定性研究表明，所有NLC都有能力改善防晒霜的光稳定性。体外释放研究表明，所有三个NLC显示持续释放曲线，它们与Higuchi方程相吻合。

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