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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Cardioprotective effect of magnetic hydrogel nanocomposite loaded N, alpha-L-rhamnopyranosyl vincosamide isolated from Moringa oleifera leaves against doxorubicin-induced cardiac toxicity in rats: in vitro and in vivo studies
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Cardioprotective effect of magnetic hydrogel nanocomposite loaded N, alpha-L-rhamnopyranosyl vincosamide isolated from Moringa oleifera leaves against doxorubicin-induced cardiac toxicity in rats: in vitro and in vivo studies

机译：磁性水凝胶纳米复合材料的心脏防护作用N，α-L-萘吡喃糖基叶蛋白酶从辣木植物中分离出的大鼠多柔比蛋白诱导的大码素诱导的心肌毒性：体外和体内研究

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摘要

Cardioprotective effect of N, alpha-L-rhamnopyranosyl vincosamide (VR), isolated from the leaves of Moringa oleifera plant in doxorubicin (Dox)-induced cardiac toxicity rats was evaluated. Twelve (12) rats were randomly selected into three groups; two rats received distilled water in the control group, five rats in group I received varying concentration of VR treatment, and group II containing five rats received varying concentration of VR-loaded magnetic hydrogel nanocomposite. Malondialdehyde (MDA), glutathione peroxidase (GSH) and superoxide dismutase (SOD) enzymes activities level were analysed after two weeks. In addition, the expression of three heart failure markers; beta major histocompatibility complex (beta-MHC), atrial natriuretic peptide (ANP), and B type natriuretic peptide (BNP) were also evaluated. It was observed that the level of these markers expression decreases with an increase in VR concentration (p 0.05). The reduced GSH and SOD level were increased after VR administration, this extract also reduced the initially increased MDA level in cardiac tissue. Pharmacokinetic parameters evaluation showed that nanogel treated rats possesses a significantly increased VR plasma concentration, C-max, K-el, t(1/2(a),) t(1/2(el),) K-a and AUC. The result of this study indicated that VR may help to lower the dosage level, and reduces the treatment course in cardiovascular diseases (CVD). Our conclusion proposes the cardio-protective ability of the isolated VR and its beneficial effect via free radical scavenging properties.
机译：评估了雌性蛋白（DOX）诱导的心脏毒性大鼠Moringa Oleifera植物叶片中N，α-L-鼠霉糖基叶苷（VR）的心脏保护作用。 12（12）只大鼠随机选择三组;两只大鼠在对照组中接受蒸馏水，I基团中的五只大鼠接受不同浓度的VR处理，并且含有五只大鼠的II大鼠接受了不同浓度的VR负载磁性水凝胶纳米复合材料。丙二醛（MDA），谷胱甘肽过氧化物酶（GSH）和超氧化物歧化酶（SOD）酶活性在两周后分析。此外，表达三颗心力衰竭标志物;还评估了β主要组织相容性复合物（β-MHC），心房利钠肽（ANP）和B型利钠肽（BNP）。观察到这些标志物表达的水平随VR浓度的增加而降低（P <0.05）。在VR给药后，GSH和SOD水平降低，该提取物也降低了心脏组织中最初增加的MDA水平。药代动力学参数评价表明，纳米凝胶处理的大鼠具有显着增加的VR血浆浓度，C-MAX，K-E1，T（1/2（A），）T（1/2（EL），）K-A和AUC。该研究的结果表明，VR可以有助于降低剂量水平，并降低心血管疾病（CVD）的治疗过程。我们的结论提出了孤立的VR的心脏保护能力及其通过自由基清除性能的有益效果。

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