...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Quantitative study of the production and properties of alginate/poly-L-lysine microcapsules
【24h】

Quantitative study of the production and properties of alginate/poly-L-lysine microcapsules

机译：藻酸盐/聚溶麦片微胶囊的生产和性能的定量研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Alginate-polylysine-alginate (APA) microcapsules are of particular interest for their application as implants or for bioreactor cultures. Although their formation has been widely studied, there is still a lack of quantitative data describing resistance, membrance thickness and permeability. In this study, the quantitative application of a Texture Analyser for the measurement of capsule deformation yielded important results that permit comparison with other polymer systems used for encapsulation. Furthermore, single-membrane and multi-membrane capsules were formed in order to improve the modulation of the capsule properties. For single-membrane capsules, resistance was mostly affected by the incubation time in poly-L-lysine (PLL), the PLL molecular weight and concentration. The increase in resitance from 0.1 (+-) 0.01 g/capsules to 2 (+-) 0.2 g/capsules was linked to a membrane thickening (35-120 mum) and a decrease in permeability (150 to 40 kD). Thus, it was not possible to modify resistance and membrane permeability independently. Multi-membrane capsules with a resistance comparable to single-membrane capsules could be formed using various combinations of PLL molecular weights, and enabled uncoupling of permeability and resistance properties.
机译：藻酸盐 - 聚硅酸盐 - 藻酸盐（APA）微胶囊特别感兴趣的是它们作为植入物或生物反应器培养物的应用。虽然它们的形成已被广泛研究，但仍然缺乏描述阻力，膜厚度和渗透性的定量数据。在该研究中，纹理分析仪用于测量胶囊变形的定量应用产生了重要的结果，允许与用于封装的其他聚合物系统进行比较。此外，形成单膜和多膜胶囊，以改善胶囊性能的调节。对于单膜胶囊，抗性主要受到聚-1-赖氨酸（PLL）中的孵育时间的影响，PLL分子量和浓度。从0.1（+ - ）0.01g /胶囊到2（+ - ）0.2g /胶囊的分析增加与膜增稠（35-120mum）连接，渗透性降低（150-40kd）。因此，不可能独立地改变抗性和膜渗透性。使用与单膜胶囊相当的多膜胶囊可以使用PLL分子量的各种组合形成，并且能够使渗透性和抗性性能的脱模。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号