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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Curcumin entrapped hyaluronan containing niosomes:preparation,characterisation and in vitro/in vivo evaluation
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Curcumin entrapped hyaluronan containing niosomes:preparation,characterisation and in vitro/in vivo evaluation

机译：姜黄素捕获的透明质酸含有定位素：制备，表征和体外/体内评价

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Curcumin,a natural polyphenols compound,has numerous pharmacological activities;while it faces several bioavailability problems,due to its poor solubility and stability.So,many nano-structures have been designed to overcome these drawbacks.The aim of this study was to prepare a polymeric niosomal structure by incorporating hyaluronan to improve curcumin efficiencies.Hyaluronan containing niosomes were prepared by thin film hydration medium with slight modifications.In the formulation of hyaluronan containing niosomes size and zeta potential studies,Atomic Force Microscopy(AFM),Transmission Electron Microscopy(TEM),Scanning Electron Microscopy(SEM),Differential Scanning Calorimetry(DSC),X-Ray Diffraction(XRD),in-vitro release test,DPPH antioxidant assay and in-vivo anti-inflammatory test were investigated.The results showed that hyaluronan containing niosomes were 249.83 +6.38 nm and the entrapment of curcumin was 98.28 ±0.278%(w/w).In addition,the shape of the hyaluronan containing niosomes was spherical.500 μl of the prepared formulation with 4.002 ×10~(-7)moles of curcumin showed 100% antioxidant effect.Moreover,the anti-inflammatory effect of the hyaluronan containing niosomes was higher than the anti-inflammatory effect of the simple suspension of curcumin.
机译：姜黄素是天然多酚化合物，具有许多药理学活动;而它面临着几种生物利用度问题，因为它的溶解度和稳定性差。所以，许多纳米结构旨在克服这些缺点。本研究的目的是制备通过将透明质酸掺入改善姜黄素效率的聚合物性憩室结构。通过薄膜水合介质通过薄膜水合介质具有轻微的修饰来制备含硫酸核酸核酸核糖体。在含有定位素尺寸和Zeta潜在研究的透明质酸的制剂中，原子力显微镜（AFM），透射电子显微镜（TEM ），研究了扫描电子显微镜（SEM），差示扫描量热法（DSC），X射线衍射（XRD），体外释放试验，DPPH抗氧化试验和体内抗炎试验。结果表明透明质酸含有定位素为249.83 + 6.38nm，姜黄素的夹带为98.28±0.278％（w / w）。此外，含有NiO的透明质酸的形状有些样品是球形的.500μL制备的制备配方用4.002×10〜（-7）摩洛蛋白显示出100％的抗氧化效果。寄生虫的抗炎作用高于抗炎作用的抗炎作用高于抗炎作用姜黄素的简单悬浮液。

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