Development ofin vitro2D and 3D microelectrode arrays and their role in advancing biomedical research

Didier Charles M.; Kundu Avra; DeRoo David; Rajaraman Swaminathan

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Development ofin vitro2D and 3D microelectrode arrays and their role in advancing biomedical research

机译：vitro2d和3D微电极阵列的开发及其在推进生物医学研究中的作用

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The development of microelectrode arrays (MEAs) along with complementary advances in electronics, mechanics and software to connect with these arrays has led to thein vitrointerfacing and benchtop electrophysiological models of several electrically active cells such as neurons and cardiomyocytes proving vital models and testing of human disease conditions in a dish/on a chip. This topical review deals with the micro/nanofabrication technology development of Microelectrodes Arrays from early silicon based developments to today's additive manufacturing technologies that have been employed to address bio-micro-electro-mechanical systems tool development in this space. Specifically 2D and 3D MEAs technologies have been reviewed in this paper along with a broad overview of some of the biological applications using these devices that are advancing the very state of biomedical research.

机译：微电极阵列（MEAS）的发展以及与这些阵列连接的电子设备，力学和软件的互补进展已经导致玻璃葡萄蛋白，诸如神经元和心肌细胞的几个电活性细胞的台式电生理模型，证明了人类疾病的重要模型和测试盘子/芯片上的条件。本次要综述涉及从基于硅的早期硅的微电极阵列进行微电极阵列的微观/纳米制作技术开发，这是当今的添加剂制造技术，这些技术已经用于解决这种空间中的生物微电机机械系统工具开发。本文已审查了2D和3D MEAS技术，同时综述了一些使用这些设备推进生物医学研究的设备的一些生物应用。

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来源
《Journal of Micromechanics and Microengineering》 |2020年第10期|共28页
作者
Didier Charles M.; Kundu Avra; DeRoo David; Rajaraman Swaminathan;
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Univ Cent Florida NanoSci Technol Ctr 4353 Scorpius St Res 1 Suite 231 Orlando FL 32816 USA;

Univ Cent Florida NanoSci Technol Ctr 4353 Scorpius St Res 1 Suite 231 Orlando FL 32816 USA;

Univ Cent Florida NanoSci Technol Ctr 4353 Scorpius St Res 1 Suite 231 Orlando FL 32816 USA;

Univ Cent Florida NanoSci Technol Ctr 4353 Scorpius St Res 1 Suite 231 Orlando FL 32816 USA;

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原文格式 PDF
正文语种 eng
中图分类微电子学、集成电路（IC）;
关键词
planar microelectrode arrays; three-dimensional microelectrode arrays; electrogenic cell applications; in vitroassays;

机译：平面微电极阵列;三维微电极阵列;电池应用;在vitroassays;

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1. Development ofin vitro2D and 3D microelectrode arrays and their role in advancing biomedical research [J] . Didier Charles M., Kundu Avra, DeRoo David, Journal of Micromechanics and Microengineering . 2020,第10期

机译：vitro2d和3D微电极阵列的开发及其在推进生物医学研究中的作用
2. Low melting point metal-based flexible 3D biomedical microelectrode array by phase transition method [J] . Guo Shengxin, Lin Rongzan, Wang Lei, Materials science & engineering . 2019,第Juna期

机译：低熔点金属基柔性3D生物医学微电极阵列逐相变法
3. Low melting point metal-based flexible 3D biomedical microelectrode array by phase transition method [J] . Guo Shengxin, Lin Rongzan, Wang Lei, Materials science & engineering, C. Materials for Biogical applications . 2019,第期

机译：低熔点金属基柔性3D生物医学微电极阵列逐相变法
4. Fabrication and Characterization of 3D Microelectrode Arrays (3D MEAs) with "Edge-Wrapped" Metal Interconnects and 3D-Printed Assembly Rigs for Simultaneous Optical and Electrical Probing of Nerve-on-a-Chip® Constructs [C] . Charles M. Didier, Corey Rountree, Julia Freitas Orrico, IEEE International Conference on Micro Electro Mechanical Systems . 2021

机译：3D微电极阵列的制造与表征3D微电极阵列，“边缘缠绕”金属互连和3D印刷组装钻机，用于同时光学和电气探测WORM-ON-CHIP®构建体
5. Development of optical-based array devices using imaging fiber bundles: Optical tweezer arrays, nanoscale arrays, and microelectrode arrays. [D] . Tam, Jenny M. 2005

机译：使用成像光纤束开发基于光学的阵列设备：光学镊子阵列，纳米级阵列和微电极阵列。
6. Modification of Microelectrode Arrays with High Surface Area Dendritic Platinum 3D Structures: Enhanced Sensitivity for Oxygen Detection in Ionic Liquids [O] . Ghulam Hussain, Anthony P. O’Mullane, Debbie S. Silvester 2018

机译：具有高表面积树突状铂3D结构的微电极阵列的修改：增强了离子液体中氧气检测的灵敏度。
7. How to achieve sub-cellular-level spatial resolution and sub-spike-level temporal resolution at same time is still a technical challenge in neural mapping while both information are critically important to advance neural science. Here, we present penetrating arrays consisted of single-neuron level transparent microelectrodes with low impedance coating which could realize the high spatial and temporal resolution at the same time. These 32-channel transparent penetrating electrodes with record-small site area, 225 µm², have a low impedance of ~ 149 kΩ at 1 kHz, an adequate charge injection limit of ± 0.76 mC/cm2, and up to 100 yield. Mechanical bending test result show robust mechanism up to 1000 bending cycles. After a temporary stiffen with polyethylene glycol, this electrode achieved great insertion result without any buckling or deformation. Together these results establish a novel neurotechnology - penetrating arrays of transparent, flexible bilayernanomeshMicroelectrodes which possess great potential for brain research [O] . Zhan Shi -1

机译：如何在同一时间实现子蜂窝级空间分辨率和子峰值级时间分辨率在神经映射中仍然是技术挑战，而两个信息对于推进神经科学来说都很重要。这里，我们提出穿透阵列由单神经元级透明微电极组成，具有低阻抗涂层，其可以同时实现高空间和时间分辨率。这些32通道透明穿透电极具有记录小的部位面积，225μm²的低阻抗在1 kHz的〜149kΩ的低阻抗，充足的电荷注入极限为±0.76mc / cm2，率高达100％。机械弯曲试验结果显示高达1000个弯曲循环的强大机制。在用聚乙二醇进行临时变硬后，该电极实现了很大的插入结果，而无需任何屈曲或变形。这些结果共同建立了一种新型神经技术 - 穿透透明，灵活的双层圆形脉冲阵列，其具有巨大的大脑研究潜力

Development ofin vitro2D and 3D microelectrode arrays and their role in advancing biomedical research

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