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首页> 外文期刊>Journal of Micromechanics and Microengineering >Easy-to-operate fabrication of tapered glass capillaries for microdroplet generation
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Easy-to-operate fabrication of tapered glass capillaries for microdroplet generation

机译：易于操作的微型玻璃毛细管制作微型玻璃毛细管

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摘要

Tapered glass capillaries play an important role in microdroplet generation and related microfluidic applications such as particle synthesis, digital PCR and microrectors. However, its controlled production poses a challenge. Specifically, there is difficulty controlling the tip sizes of capillaries with good repeatability at an affordable cost, which is critical to produce standard droplets for use by research groups. To produce tapered capillaries, micro needle geometries are first pulled by a commercial pipette puller, which yields a sharp tip (i.e. 1-3 mu m). Those tips need to be enlarged and standardized by post microfabrication. Although larger tips could be achieved by advanced pulling-forging, sanding-forging or breakingforging methods, the uniformity and repeatability do not meet the requirements for mass production. In this paper, several easy-to-operate fabrication approaches, including mechanical and chemical fabrication methods, are studied. Chemical etching fabrication method shows good repeatability and robust control of dimensions. A capillary droplet microfluidic device assembled by tapered glass capillaries fabricated by chemical etching method is also presented, which shows good performance for droplet generations. This non-labor intensive fabrication is straightforward and be readily adopted for industrial scale mass production.
机译：锥形玻璃毛细管在Microdroplet生成和相关的微流体应用中起重要作用，例如颗粒合成，数字PCR和微小器。然而，其受控生产造成挑战。具体地，以实惠的成本，难以控制具有良好重复性的毛细管的尖端尺寸，这对于生产用于研究组的标准液滴至关重要。为了产生锥形毛细血管，首先由商用移液管拉动器拉动微针几何形状，从而产生尖锐的尖端（即1-3μm）。通过后微制造需要扩大和标准化这些提示。尽管通过先进的拉动锻造，砂磨锻造或破碎方法可以实现较大的尖端，但均匀性和重复性不符合批量生产的要求。本文研究了几种易于操作的制造方法，包括机械和化学制造方法。化学蚀刻制造方法显示出良好的重复性和对尺寸的鲁棒控制。还介绍了由化学蚀刻方法制造的锥形玻璃毛细管组装的毛细管液滴微流体装置，其显示出液滴后的良好性能。这种非劳动强化制造是简单的，并且可以易于用于工业规模批量生产。

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