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首页> 外文期刊>Journal of Micromechanics and Microengineering >Liquid-in-gas droplet microfluidics; experimental characterization of droplet morphology, generation frequency, and monodispersity in a flow-focusing microfluidic device
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Liquid-in-gas droplet microfluidics; experimental characterization of droplet morphology, generation frequency, and monodispersity in a flow-focusing microfluidic device

机译：液体液滴微流体; 流动聚焦微流体装置中液滴形态，发电频率和单分散性的实验表征

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Microfluidic techniques for production of uniform droplets usually rely on the use of two immiscible liquids (e.g. water-in-oil emulsions). It has been shown recently that a continuous gas flow instead of a second liquid carrier can be used as an alternative approach in droplet microfluidics. In this work we experimentally investigate the generation of liquid water droplets within air in flow-focusing configurations. Over a wide range of flow conditions we identify six distinct flow regimes inside the microchannel: Co-flowing, Threading, Plugging, Dripping, Multi-Satellite Formation, and Jetting. Flow regimes and their transitions are plotted and characterized based on the Weber number (We) of the system. We further investigate the impact of liquid microchannel size on the flow maps. Generation frequency, morphology, and monodispersity of the droplets are characterized in more detail in the Dripping regime. Generation frequency can be related to the product of the liquid and gas flow rates. However, droplet morphology (length and width) is more dependent on the gas flow rate. We demonstrate the production of monodisperse droplets (d < 100 mu m and sigma/d < 5 %) up to kHz formation rates in liquid-gas microfluidic systems for the first time. The results of this work provide practical and useful guidelines for precise, oil-free delivery of ultra-small volumes of fluid which can be integrated in lab-on-a-chip systems for a variety of applications in biochemical research and material synthesis.
机译：用于生产均匀液滴的微流体技术通常依赖于使用两个不混溶的液体（例如油油乳液）。最近已经表明，连续气流代替第二液体载体可以用作液滴微流体中的替代方法。在这项工作中，我们通过实验研究流动聚焦配置中空气中的液体水滴的产生。在各种流动条件下，我们在微通道内识别六个不同的流动制度：共流，穿线，堵塞，滴水，多卫星形成和喷射。基于系统的韦伯号（我们）绘制和表征流动制度及其转变。我们进一步研究了液体微通道尺寸对流量图的影响。液滴的产生频率，形态和单分散性在滴水状态下更详细地表征。发电频率可以与液体和气流速率的产物有关。然而，液滴形态（长度和宽度）更依赖于气体流速。我们首次证明了在液体气体微流体系统中产生的单分散液滴（D <100μm和sigma / d <5％）的产生。这项工作的结果提供了实用和有用的准则，用于精确，无油递送超小体积的液体，可集成在芯片上的实验室系统中，用于生化研究和材料合成中的各种应用。

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