Visualization of intrathecal delivery by PET-imaging

Glud Andreas Norgaard; Jakobsen Steen; Landau Anne M.; Alstrup Aage Kristian Olsen; Sorensen Jens Christian Hedemann

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Visualization of intrathecal delivery by PET-imaging

机译：宠物成像可视化鞘内递送

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Background: Intrathecal (IT) delivery is useful in both basic research and clinical treatments. Here we aim to test a new minimally invasive distribution route to the subarachnoid space (SAS) and the flow of IT administrations. We placed a radioligand into SAS during positron emission tomography (PET) scanning as a proof of concept.

机译：背景：鞘内（IT）递送可用于基本研究和临床治疗方法。在这里，我们的目标是测试蛛网膜下腔空间（SAS）的新的微创分配路由和IT主管部门的流程。在正电子发射断层扫描（PET）扫描期间，将放射性配体放入SAS作为概念证明。

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来源
《Journal of Neuroscience Methods》 |2019年第2019期|共4页
作者
Glud Andreas Norgaard; Jakobsen Steen; Landau Anne M.; Alstrup Aage Kristian Olsen; Sorensen Jens Christian Hedemann;
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作者单位

Aarhus Univ Hosp Dept Neurosurg CENSE Aarhus Denmark;

Aarhus Univ &

Hosp Dept Nucl Med Aarhus Denmark;

Aarhus Univ &

Hosp Dept Nucl Med Aarhus Denmark;

Aarhus Univ &

Hosp Dept Nucl Med Aarhus Denmark;

Aarhus Univ Hosp Dept Neurosurg CENSE Aarhus Denmark;

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正文语种 eng
中图分类人体生理学;
关键词
Intrathecal delivery; Large animal model; Pharmaceutical target in subarachnoid space; PET;

机译：鞘内分娩;大型动物模型;蛛网膜下腔空间中的药物靶标;宠物;

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1. Visualization of intrathecal delivery by PET-imaging [J] . Glud Andreas Norgaard, Jakobsen Steen, Landau Anne M., Journal of Neuroscience Methods . 2019,第期

机译：宠物成像可视化鞘内递送
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6. Intrathecal delivery of fluorescent labeled butyrylcholinesterase to the brains of butyrylcholinesterase knock-out mice: Visualization and quantification of enzyme distribution in the brain [O] . Noel D. Johnson, Ellen G. Duysen, Oksana Lockridge -1

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7. Intrathecal delivery of fluorescent labeled butyrylcholinesterase to the brains of butyrylcholinesterase knock-out mice: Visualization and quantification of enzyme distribution in the brain [O] . Noel D. Johnson, Ellen G. Duysen, Oksana Lockridge 2009

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Visualization of intrathecal delivery by PET-imaging

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