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首页> 外文期刊>Journal of Neuroscience Methods >Cerebral venous sinus thrombosis: Developing an experimental model.
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Cerebral venous sinus thrombosis: Developing an experimental model.

机译：脑静脉窦血栓形成：发展实验模型。

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摘要

To develop a simple experimental model for cerebral venous sinus thrombosis in rat, 24 male Sprague-Dawley rats (14 experimental and 10 controls) were studied. After anesthesia, a 1.5mmx10mm cranial window was made to expose superior sagittal sinus (SSS). A filter paper strip soaked in 40% ferric chloride topically applied for 5min to induce SSS thrombosis in experimental group. Five of these rats underwent autopsy at 24h after rota rod study, other 9 rats underwent MRI after 24h followed by autopsy at 36-48h. On MRI, T2 hyperintense lesions were seen in all 9 rats of study group but none in controls. On autopsy, TTC staining revealed changes in 7 out of 14 experimental rats but in none of the controls. The rota rod study results revealed an insignificant difference in the experimental and control group. There was no spontaneous death in experimental or control group during the study. The present experimental model is simple, easy to carry out and results in TTC staining changes in 50% and T2 hyperintensity on MRI in all which could be due to SSS thrombosis.
机译：为了开发大鼠大鼠脑静脉血栓形成的简单实验模型，研究了24例雄性Sprague-Dawley大鼠（14个实验和10个对照）。麻醉后，使1.5mmx10mm的颅窗暴露出卓越的矢状窦（SSS）。浸泡在40％氯化氯化铁的过滤纸条局部施用5分钟，以诱导实验组中的SSS血栓形成。在罗塔杆研究后24小时后，这些大鼠中的五只尸检，其他9只大鼠在24小时后接受MRI，然后在36-48小时后进行尸检。在MRI，在所有9只研究组中看到T2高压病变，但没有控制。在尸检上，TTC染色显示14例实验大鼠中的7种，但没有任何对照。罗塔杆研究结果显示实验和对照组的微不足道差异。在研究期间，实验或对照组没有自发死亡。本实验模型简单，易于进行，导致TTC染色在MRI上的50％和T2超高度的变化，所有这些都可能是由于SSS血栓形成。

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