The M-Maze task: An automated method for studying fear memory in rats exposed to protracted aversive conditioning

Souza Rimenez R.; Robertson Nicole M.; Pruitt David T.; Noble Lindsey; Meyers Eric C.; Gonzales Phillip A.; Bleker Nathaniel P.; Carey Holle L.; Hays Seth A.; Kilgard Michael P.; McIntyre Christa K.; Rennaker Robert L.

首页> 外文期刊>Journal of Neuroscience Methods >The M-Maze task: An automated method for studying fear memory in rats exposed to protracted aversive conditioning

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The M-Maze task: An automated method for studying fear memory in rats exposed to protracted aversive conditioning

机译：M-MAZE任务：用于研究暴露于暴露于持久厌档调理的大鼠中恐惧记忆的自动化方法

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Background: Fear conditioning (FC) in rodents is the most used animal model to investigate the neurobiology of posttraumatic stress disorder (PTSD). Although research using FC has generated a better understanding of fear memories, studies often rely on mild or moderate FC training and behavioral analysis generally focuses on measuring freezing responses within few test sessions.

机译：背景：啮齿动物中的恐惧调节（FC）是探讨术后胁迫障碍（PTSD）的神经生物学的最常用的动物模型。虽然使用FC的研究产生了更好地了解恐惧记忆，但研究通常依赖于温和或中度的FC培训和行为分析，通常侧重于测量少数试验中的冻结响应。

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来源
《Journal of Neuroscience Methods》 |2018年第2018期|共12页
作者
Souza Rimenez R.; Robertson Nicole M.; Pruitt David T.; Noble Lindsey; Meyers Eric C.; Gonzales Phillip A.; Bleker Nathaniel P.; Carey Holle L.; Hays Seth A.; Kilgard Michael P.; McIntyre Christa K.; Rennaker Robert L.;
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作者单位

Univ Texas Dallas Texas Biomed Device Ctr 800 West Campbell Rd Richardson TX 75080 USA;

Univ Texas Dallas Texas Biomed Device Ctr 800 West Campbell Rd Richardson TX 75080 USA;

Univ Texas Dallas Texas Biomed Device Ctr 800 West Campbell Rd Richardson TX 75080 USA;

Univ Texas Dallas Texas Biomed Device Ctr 800 West Campbell Rd Richardson TX 75080 USA;

Univ Texas Dallas Texas Biomed Device Ctr 800 West Campbell Rd Richardson TX 75080 USA;

Univ Texas Dallas Texas Biomed Device Ctr 800 West Campbell Rd Richardson TX 75080 USA;

Univ Texas Dallas Texas Biomed Device Ctr 800 West Campbell Rd Richardson TX 75080 USA;

Univ Texas Dallas Texas Biomed Device Ctr 800 West Campbell Rd Richardson TX 75080 USA;

Univ Texas Dallas Texas Biomed Device Ctr 800 West Campbell Rd Richardson TX 75080 USA;

Univ Texas Dallas Texas Biomed Device Ctr 800 West Campbell Rd Richardson TX 75080 USA;

Univ Texas Dallas Texas Biomed Device Ctr 800 West Campbell Rd Richardson TX 75080 USA;

Univ Texas Dallas Texas Biomed Device Ctr 800 West Campbell Rd Richardson TX 75080 USA;

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原文格式 PDF
正文语种 eng
中图分类人体生理学;
关键词
Extinction; Fear; M-Maze; Protracted aversive conditioning; PTSD; Single prolonged stress;

机译：灭绝;恐惧;M-迷宫;持久的厌恶调理;PTSD;单延长的压力;

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专利

1. The M-Maze task: An automated method for studying fear memory in rats exposed to protracted aversive conditioning [J] . Souza Rimenez R., Robertson Nicole M., Pruitt David T., Journal of Neuroscience Methods . 2018,第期

机译：M-MAZE任务：用于研究暴露于暴露于持久厌档调理的大鼠中恐惧记忆的自动化方法
2. Paradoxical mineralocorticoid receptor-mediated effect in fear memory encoding and expression of rats submitted to an olfactory fear conditioning task [J] . SouzaR.R., DalBóS., DeKloetE.R., Neuropharmacology . 2014,第Null期

机译：拟南芥盐皮质激素受体介导的嗅觉恐惧调节大鼠的恐惧记忆编码和表达的作用。
3. Assessing the interplay between fear and learning in mice exposed to a live rat in a spatial memory task (MWM). [J] . Bonsignore LT, Chiarotti F, Alleva E, Animal Cognition . 2008,第3期

机译：在空间记忆任务（MWM）中评估暴露于活鼠的小鼠的恐惧与学习之间的相互作用。
4. Visual and pain pathways involved in fear conditioning measured with fear-potentiated startle: behavioral and anatomic studies [C] . Changjun Shi, Davis, M. . 2002

机译：通过恐惧增强的惊吓测量恐惧调节中涉及的视觉和疼痛途径：行为和解剖学研究
5. Contributions of the Renin Angiotensin System to Fear Memory and Fear Conditioned Cardiovascular Responses [D] . Swiercz, Adam . 2020

机译：肾素血管紧张素系统恐惧记忆和恐惧条件心血管反应的贡献
6. Relationship between Fear Conditionability and Aversive Memories: Evidence from a Novel Conditioned-Intrusion Paradigm [O] . Melanie Wegerer, Jens Blechert, Hubert Kerschbaum, -1

机译：恐惧可调节性与厌恶记忆之间的关系：来自新型条件入侵范例的证据
7. Relationship between fear conditionability and aversive memories: evidence from a novel conditioned-intrusion paradigm. [O] . Melanie Wegerer, Jens Blechert, Hubert Kerschbaum, 2013

机译：恐惧条件性和厌恶记忆之间的关系：来自一种新颖的条件侵入范式的证据。
8. Oxytocin and Social Support as Synergistic Inhibitors of Aversive Fear Conditioning and Fear-Potentiated Startle in Male Rats [R] . Rosen, J. 2011

机译：催产素和社会支持作为雄性大鼠厌食恐惧和恐惧增强惊恐的协同抑制剂

The M-Maze task: An automated method for studying fear memory in rats exposed to protracted aversive conditioning

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