Characterisation of progressive motor deficits in whisker movements in R6/2, Q175 and Hdh knock-in mouse models of Huntington's disease

Garland Huw; Wood Nigel I.; Skillings Elizabeth A.; Detloff Peter J.; Morton A. Jennifer; Grant Robyn A.

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Characterisation of progressive motor deficits in whisker movements in R6/2, Q175 and Hdh knock-in mouse models of Huntington's disease

机译：R6 / 2，Q175和HDH敲击在亨廷顿疾病鼠标模型中的晶须运动中渐进电机缺陷的特征

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Background: Motor dysfunction is a major component of the Huntington's disease (HD) phenotype, both in patients and animal models. Motor function in mice is usually measured using tests that involve a novel environment, or require a degree of learning, which creates potential confounds in animals, such as anxiety and/or learning.

机译：背景：电动机功能障碍是亨廷顿病（HD）表型的主要组成部分，患者和动物模型。小鼠中的电机功能通常使用涉及新环境的测试来测量，或者需要学习程度，这在动物中产生潜在的混淆，例如焦虑和/或学习。

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来源
《Journal of Neuroscience Methods》 |2018年第2018期|共9页
作者
Garland Huw; Wood Nigel I.; Skillings Elizabeth A.; Detloff Peter J.; Morton A. Jennifer; Grant Robyn A.;
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作者单位

Univ Cambridge Dept Physiol Dev &

Neurosci Downing St Cambridge CB2 3DY England;

Univ Cambridge Dept Physiol Dev &

Neurosci Downing St Cambridge CB2 3DY England;

Univ Cambridge Dept Physiol Dev &

Neurosci Downing St Cambridge CB2 3DY England;

Univ Alabama Birmingham Dept Biochem &

Mol Genet KAUL 540 720 20th St South Birmingham AL 35294;

Univ Cambridge Dept Physiol Dev &

Neurosci Downing St Cambridge CB2 3DY England;

Manchester Metropolitan Univ Div Biol &

Conservat Ecol Chester St Manchester M1 5GD Lancs;

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原文格式 PDF
正文语种 eng
中图分类人体生理学;
关键词
Rodent behaviour; Active sensing; Motor control; Huntington's disease; Whisking;

机译：啮齿动物行为;活性感应;电机控制;亨廷顿的疾病;搅拌;

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专利

1. Characterisation of progressive motor deficits in whisker movements in R6/2, Q175 and Hdh knock-in mouse models of Huntington's disease [J] . Garland Huw, Wood Nigel I., Skillings Elizabeth A., Journal of Neuroscience Methods . 2018,第期

机译：R6 / 2，Q175和HDH敲击在亨廷顿疾病鼠标模型中的晶须运动中渐进电机缺陷的特征
2. Progression of behavioural despair in R6/2 and Hdh knock-in mouse models recapitulates depression in Huntington's disease [J] . Alessro Ciamei, Peter J. Detloff, A. Jennifer Morton Behavioural Brain Research: An International Journal . 2015,第Null期

机译：R6 / 2和HDH敲击小鼠模型中的行为绝望的进展促进了亨廷顿疾病的抑郁症
3. Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease [J] . Jin Jing, Peng Qi, Hou Zhipeng, Human Molecular Genetics . 2015,第9期

机译：亨廷顿舞蹈病的新型敲入小鼠模型中的早期白质异常，进行性脑病理学和运动功能障碍
4. Neurorobotic Approach to Study Huntington Disease Based on a Mouse Neuromusculoskeletal Model [C] . Satoshi Oota, Yuko Okamura-Oho, Ko Ayusawa, IEEE/RSJ International Conference on Intelligent Robots and Systems . 2018

机译：基于小鼠神经肌肉骨骼模型的神经机器人方法研究亨廷顿病
5. A neuroanatomical analysis of striosome-matrix compartmentalization and motor deficits in YAC mouse models of Huntington's disease. [D] . Lawhorn, Collene. 2009

机译：在亨廷顿舞蹈病的YAC小鼠模型中，纹状体-基质分隔和运动缺陷的神经解剖学分析。
6. Early white matter abnormalities progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntingtons disease [O] . Jing Jin, Qi Peng, Zhipeng Hou, -1

机译：亨廷顿舞蹈病的新型敲入小鼠模型中的早期白质异常进行性脑病理学和运动功能障碍
7. Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease [O] . Jing Jin, Qi Peng, Zhipeng Hou, 2015

机译：早期白质异常，进步脑病理和电机缺陷在亨廷顿氏病的新敲击小鼠模型中

Characterisation of progressive motor deficits in whisker movements in R6/2, Q175 and Hdh knock-in mouse models of Huntington's disease

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