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首页> 外文期刊>Journal of oncology pharmacy practice: official publication of the International Society of Oncology Pharmacy Practitioners >Can ethanol intoxication secondary to docetaxel be predicted based on dose administered using a point-of-care saliva ethanol test?
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Can ethanol intoxication secondary to docetaxel be predicted based on dose administered using a point-of-care saliva ethanol test?

机译：基于使用护理点唾液乙醇试验施用的剂量来预测乙醇中毒是否仲成Docetaxel？

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Background The Food and Drug Administration issued a drug safety alert highlighting the potential association of docetaxel infusion with signs and symptoms of alcohol intoxication. This concern is significant because patients treated with docetaxel often have comorbidities and are prescribed concomitant centrally active medications. As a result, these patients may be at risk for iatrogenic events. Objective The objective of this study was to identify a correlation with docetaxel infusion and saliva ethanol concentration using a point-of-care ethanol test. Methods In this pilot study, ethanol concentrations were measured using a validated saliva ethanol test in patients receiving intravenous docetaxel as part of their chemotherapy regimen. Both ethanol dose and infusion rate were calculated based on the amount of the specific docetaxel product administered. Saliva ethanol concentrations were measured at baseline, immediately after infusion completion, and at 30 and 60 min postinfusion. Results A total of 17 patients were included in the analysis. The mean ethanol dose administered was 2.6 +/- 0.5 g of ethanol per infusion of docetaxel with a mean infusion rate of 3.2 +/- 0.7 ml of ethanol per hour. At baseline, immediately after infusion, and 30 and 60 min postinfusion, all patients had a saliva ethanol test result of 0 mg/dl. Conclusion Based on this small pilot study, the prediction of patients who will experience ethanol intoxication using a point-of-care saliva ethanol test based on the docetaxel dose administered is challenging. This observation requires confirmation in larger and more heterogeneous populations.
机译：背景技术食品和药物管理局发出了一种药物安全警报，突出了多西紫杉醇输注与酒精中毒的症状和症状的潜在协会。这种担忧是显着的，因为通过多西紫杉醇治疗的患者通常具有合并症，并且规定伴随着伴随的中央活性药物。因此，这些患者可能面临认可事件的风险。目的通过使用护理点乙醇试验，本研究的目的是鉴定与多西紫杉醇输注和唾液乙醇浓度的相关性。方法在该试验研究中，使用验证的唾液乙醇试验测量乙醇浓度，所述唾液乙醇试验在接受静脉内多西紫杉醇作为其化疗方案的一部分。基于所施用的特异性多西紫杉醇产物的量计算乙醇剂量和输注速率。唾液乙醇浓度在基线下测量，在输注完成后立即测量，并在30分钟和60分钟灌注。结果分析中共有17名患者。施用的平均乙醇剂量为2.6 +/- 0.5g乙醇的每小时输液3.2 +/- 0.7ml乙醇的平均输注速率。在排入后立即在基线下，随着30次和60分钟灌注，所有患者均具有0mg / dl的唾液乙醇试验结果。结论基于这项小型试点研究，使用基于多西紫杉醇剂量的医疗点唾液乙醇试验对乙醇中毒进行患者的预测是挑战。该观察结果需要在较大和更异质的人群中确认。

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