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首页> 外文期刊>Journal of oncology pharmacy practice: official publication of the International Society of Oncology Pharmacy Practitioners >A retrospective analysis of clinical acuity markers on hospital length of stay in patients with febrile neutropenia
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A retrospective analysis of clinical acuity markers on hospital length of stay in patients with febrile neutropenia

机译：临床敏锐性标志物临床敏锐度患者临床敏锐性患者患者

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Objective The primary objective of this study was to identify factors that have predictive value in determining total hospital length of stay in patients with febrile neutropenia, particularly time to first antibiotic dose. Methods This study was a retrospective chart review analyzing patients admitted to a 443 bed tertiary county teaching hospital from 1 November 2010 through 1 November 2015. Patients were eligible for enrollment into the study if they met Infectious Diseases Society of America accepted criteria for febrile neutropenia. Results Ninety-three patients were included for analysis. Time to first antibiotic dose, first empirically appropriate antibiotic dose, and time to first isolate-appropriate antibiotic did not show a significant correlation to total hospital length of stay (p?=?0.71, p?=?0.342, and p?=?0.77, respectively). Subject’s Multinational Association for Supportive Care in Cancer and Simplified Acute Physiology II scores were significantly correlated with hospital lengths of stay (p?=?0.0052, rs?=??0.243 and p?=?0.0001, rs?=?0.344, respectively). Higher median (interquartile ranges) Simplified Acute Physiology II scores were also associated with hospital mortality [dead?=?46 (34.8–51.7) vs. alive?=?34 (28–43.3), p?=?0.0173]. Conclusions Measures of patient acuity, such as the Multinational Association for Supportive Care in Cancer and Simplified Acute Physiology II scores, did show a correlation to clinical outcomes in patients with febrile neutropenia. Timing of initial antibiotics between 2.32 and 6.27 hours after presentation in patients with febrile neutropenia did not correlate with clinical outcomes.
机译：目的本研究的主要目标是识别在发热中性粒细胞病患者中确定总医院住院时间的预测价值，特别是第一次抗生素剂量的时间。方法本研究是一项回顾性图表，分析了2010年11月1日至11月1日至11月1日至2015年11月1日入院的患者。如果他们达到美国传染病学会，患者有资格参加该研究。结果含有93名患者进行分析。是第一次抗生素剂量的时间，首先经验施用适当的抗生素剂量，以及第一种分离attate-Photal抗生素的时间没有显示出与总医院的逗留时间显着相关（p？= 0.71，p？= 0.342和p？=？ 0.77分别）。受试者的跨国关联癌症和简化的急性生理学II分数与医院的逗留程度显着相关（P？= 0.0052，Rs？= ?? 0.243和P？=？0.0001，Rs？=？0.344分别） 。更高的中位数（胎面范围）简化的急性生理学II分数也与医院死亡率有关[死亡吗？=？46（34.8-51.7）与活着？=？34（28-43.3），p？= 0.0173]。结论患者敏锐度的措施，如癌症和简化急性生理学II分数的跨国关联，确实表现出与发热中性粒细胞率患者患者的临床结果相关。患有22.32和6.27小时后的初始抗生素的时间介绍，患有Febrile Neutropenia患者与临床结果不相关。

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