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首页> 外文期刊>Journal of oncology pharmacy practice: official publication of the International Society of Oncology Pharmacy Practitioners >Recurrent cisplatin hypersensitivity reaction after first exposure: A case report
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Recurrent cisplatin hypersensitivity reaction after first exposure: A case report

机译：第一次暴露后复发性顺铂过敏反应：案例报告

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Purpose Hypersensitivity reactions to platinum-based chemotherapies are well documented and are often a limiting factor in treating a variety of cancers. Allergy skin testing has been used to determine if repeat exposure is safe. We report a case of a false negative skin allergy test in an atypical presentation of cisplatin hypersensitivity reaction. Case report A 64-year-old male diagnosed with stage IVa squamous cell carcinoma of the hypopharynx who developed a delayed reaction of face swelling and dysphagia following exposure to a single dose of cisplatin. Skin allergy testing performed and was negative. On second dosing of cisplatin, the patient developed an immediate hypersensitivity reaction. Cisplatin was discontinued, and the patient was transitioned to cetuximab. The rest of chemoradiation therapy was completed without further incident. Discussion This case demonstrates the limited efficacy of skin allergy testing for cisplatin. Furthermore, it is an atypical presentation of cisplatin-related hypersensitivity as it occurred following the patient's first dose despite no prior exposure to platinum-based chemotherapy. Conclusion Skin allergy testing has limited sensitivity for platinum-based chemotherapy and caution should be exercised in weighing risk and benefits of re-exposure. Although rare, cisplatin hypersensitivity can present after first exposure.
机译：目的，对铂的化学疗法的过敏反应良好记录，并且通常是治疗各种癌症的限制因素。过敏皮肤测试已被用于确定重复暴露是否安全。我们报告了在顺铂超敏反应的非典型呈现中进行假阴性皮肤过敏测试的情况。案例报告了一名64岁的男性，诊断出患有阶段IVA鳞状细胞癌的低咽喉细胞，在暴露于单剂量的顺铂之后，开发了面部肿胀和吞咽困难的延迟反应。皮肤过敏测试表演，是负面的。在第二剂量的顺铂，患者开发了立即过敏反应。停止顺铂，患者转变为甲磺酸。剩下的化学疗法无需进一步发生。讨论本例证明了Cisplatin皮肤过敏测试的有限疗效。此外，尽管在患者的第一次剂量之后，它是一种非典型的表达顺铂相关的过敏症，尽管在患者的第一剂量之后，尽管没有以前暴露于基于铂类化学疗法。结论皮肤过敏测试对铂金疗法的敏感性有限，应在称重风险和重新接触的益处时进行谨慎。虽然罕见，第一次暴露后可以存在的顺铂过敏。

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