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Acceleration of interstitial lung disease induced by raltitrexed

机译:罗尔特雷德诱导的促进间质肺病的加速度

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Introduction Raltitrexed is a folate analogue, which selectively inhibits thymidylate synthase, used in the treatment of colorectal carcinoma. Common side effects include asthenia and gastrointestinal and haematological toxicities. Case report We present the case of a 74-year-old gentleman with incidental mild interstitial lung disease on preoperative staging CT Chest who developed acute breathlessness whilst undergoing adjuvant raltitrexed treatment for a completely excised colorectal adenocarcinoma. Management and outcome Discontinuation of raltitrexed and a course of steroid therapy resulted in resolution of symptoms, mirrored by an improvement in lung function tests. Discussion The clinical pattern of rapid progression with steroid response highlights the potential for significant acceleration of interstitial lung disease by raltitrexed.
机译:引言罗尔特拉特肾上腺是一种叶酸类似物,其选择性地抑制胸苷合酶,用于治疗结肠直肠癌。 常见的副作用包括哮喘和胃肠道和血液毒性。 案例报告我们展示了一个74岁的绅士,偶然的术前分期CT胸部偶然的轻度间质肺病,虽然进行了急性呼吸的呼吸困难,但是在经过佐剂罗尔特拉特雷治疗的完全切除的结直肠癌癌症时。 罗尔特拉特雷德的管理和结果停止,并且类固醇治疗过程导致了通过改善肺功能试验的症状而导致的症状。 讨论类固醇反应快速进展的临床模式突出了罗尔特雷德对全能性肺病疾病显着加速的潜力。

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