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首页> 外文期刊>Journal of occupational and environmental medicine >Effect of Interaction Between Noise and A1166C Site of AT1R Gene Polymorphism on Essential Hypertension in an Iron and Steel Enterprise Workers
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Effect of Interaction Between Noise and A1166C Site of AT1R Gene Polymorphism on Essential Hypertension in an Iron and Steel Enterprise Workers

机译：噪声与A1166C位点相互作用的影响钢铁企业工人基本高血压的α基因多态性

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摘要

Objective: This study aimed to analyze the interaction of Angiotensin II type 1 receptor (AT1R) gene polymorphism and occupational noise on the occurrence of essential hypertension (EH) in steel and iron enterprise men workers. Methods: A case control study of 935 iron and steel enterprise men workers was conducted, which included 312 cases of hypertension and 623 cases without hypertension. The noise at the workplace was assessed. Polymorphism of AT1R of the workers was examined using polymerase chain reaction-restriction fragment length polymorphism. Results: Polymorphism of AT1R (AC_CC vs. AA, odds ratio [OR] = 1.760, 95% confidence interval [CI]: 1.061 similar to 2.920) and noise (greater than or equal to 85 dB(A), OR = 1.641, 95% CI: 1.225 similar to 2.198) were independent determinants of EH using multivariate Logistic regression. Compared with AA carriers without noise, AC_CC interacted with noise (OR = 2.519, 95% CI: 1.254 similar to 5.062) based on the multiplied model. Conclusions: AC_CC genotype of AT1R and noise were the risky factors of EH. These factors also interacted with each other.
机译：目的：本研究旨在分析血管紧张素II型1受体（AT1R）基因多态性和职业噪声对钢铁和铁企业人工必需高血压（EH）的发生的相互作用。方法：进行了935名钢铁企业工人的案例控制研究，其中包括312例高血压病例和623例没有高血压。评估了工作场所的噪音。使用聚合酶链反应限制片段长度多态性检查工人的AT1R的多态性。结果：AT1R的多态性（AC_CC与AA，差距[或] = 1.760，95％置信区间[CI]：1.061类似于2.920）和噪声（大于或等于85 dB（a），或= 1.641， 95％CI：1.225类似于2.198）是使用多元逻辑回归的EH独立的决定因素。与无噪声的AA载体相比，AC_CC基于乘以模型，ac_cc与噪声（或= 2.519,95％CI：1.254类似于5.062）。结论：AC_CC AT1R和噪声的基因型是EH的风险因素。这些因素也互相互动。

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    Tong Junwang; Wang Ying; Yuan Juxiang; Yang Jingbo; Wang Zhaoyang; Zheng Yao; Chai Feng; Li Xiangwen;

  • 作者单位

    China Med Univ Sch Publ Hlth Shenyang Peoples R China;

    North China Univ Sci &

    Technol Dept Endocrinol Affiliated Hosp Tangshan Hebei Province Peoples;

    China Med Univ Sch Publ Hlth Shenyang Peoples R China;

    Tangshan Iron &

    Steel Grp Co LTD Tangshan Peoples R China;

    Tangshan Hongci Hosp Tangshan Peoples R China;

    North China Univ Sci &

    Technol Sch Publ Hlth Hebei Prov Coal Mine Hlth &

    Safety Lab Tangshan;

    North China Univ Sci &

    Technol Sch Publ Hlth Hebei Prov Coal Mine Hlth &

    Safety Lab Tangshan;

    North China Univ Sci &

    Technol Sch Publ Hlth Hebei Prov Coal Mine Hlth &

    Safety Lab Tangshan;

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  • 正文语种 eng
  • 中图分类 劳动卫生;
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