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首页> 外文期刊>Journal of motor behavior >Combination Effects of Forced Mild Exercise and GABA(B) Receptor Agonist on Spatial Learning, Memory, and Motor Activity in Striatum Lesion Rats
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Combination Effects of Forced Mild Exercise and GABA(B) Receptor Agonist on Spatial Learning, Memory, and Motor Activity in Striatum Lesion Rats

机译：强制轻度运动和GABA（B）受体激动剂对纹状体病变大鼠空间学习，记忆和运动活性的组合效应

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摘要

Basal ganglia (BG) lesions cause impairments of different mammalian's movement and cognition behaviors. Motor circuit impairment has a dominant role in the movement disorders. An inhibitory factor in BG is GABA neurotransmitter, which is released from striatum. Lesions in GABAergic neurons could trigger movement and cognition disorders. Previous evidence showed that GABA(B) receptor agonist (Baclofen) administration in human improves movement disorders and exercise can improve neurodegenerative and cognitive decline; however, the effects of both Baclofen and mild forced treadmill exercise on movement disorders are not well known. The main objective of this study is to investigate the combined effects of mild forced treadmill exercise and microinjection of Baclofen in the internal Globus Pallidus on striatum lesion-induced impairments of spatial learning and motor activity. We used Morris water maze and open filed tests for studying spatial learning, and motor activity, respectively. Results showed that mild exercise and Baclofen microinjection could not lonely affect the spatial learning, and motor activity impairments while the combination of them could alleviate spatial learning, and motor activity impairments in striatum-lesion animals. Our results suggest that striatum lesion-induced memory and motor activity impairments can improve with combination interaction of GABA(B) receptor agonist and exercise training.
机译：基础神经节（BG）病变导致不同哺乳动物运动和认知行为的损害。电机电路损伤在运动障碍中具有显着作用。 BG的抑制因子是GABA神经递质，其从纹状体中释放。 Gabaergic神经元的病变可以触发运动和认知障碍。以往的证据表明，人类中GABA（B）受体激动剂（Baclofen）给药在人体中提高运动障碍和运动可以改善神经变性和认知下降;然而，Baclofen和温和的强制跑步机在运动障碍上的影响尚不熟知。本研究的主要目的是探讨温和强制跑步机运动和肉豆蔻蛋白的微调对纹状体病变诱导的空间学习障碍损伤的综合效果。我们使用Morris水迷宫和开放的归档测试，分别用于研究空间学习和运动活动。结果表明，温和的运动和肉氯芬显微注射不能孤独地影响空间学习，以及运动活动障碍，同时它们的结合可以缓解空间学习，以及纹状体病变动物中的电机活动障碍。我们的研究结果表明，纹状体病变诱导的记忆和运动活动损伤可以改善GABA（B）受体激动剂和运动训练的组合相互作用。

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