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首页> 外文期刊>Journal of neurology >A wearable sensor identifies alterations in community ambulation in multiple sclerosis: contributors to real-world gait quality and physical activity
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A wearable sensor identifies alterations in community ambulation in multiple sclerosis: contributors to real-world gait quality and physical activity

机译：可穿戴传感器识别多发性硬化中的社区手机的改变：实现现实世界步态和身体活动的贡献者

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People with multiple sclerosis (pwMS) often suffer from gait impairments. These changes in gait have been well studied in laboratory and clinical settings. A thorough investigation of gait alterations during community ambulation and their contributing factors, however, is lacking. The aim of the present study was to evaluate community ambulation and physical activity in pwMS and healthy controls and to compare in-lab gait to community ambulation. To this end, 104 subjects were studied: 44 pwMS and 60 healthy controls (whose age was similar to the controls). The subjects wore a tri-axial, lower back accelerometer during usual-walking and dual-task walking in the lab and during community ambulation (1 week) to evaluate the amount, type, and quality of activity. The results showed that during community ambulation, pwMS took fewer steps and walked more slowly, with greater asymmetry, and larger stride-to-stride variability, compared to the healthy controls (p < 0.001). Gait speed during most of community ambulation was significantly lower than the in-lab usual-walking value and similar to the in-lab dual-tasking value. Significant group (pwMS /controls)-by-walking condition (in-lab/community ambulation) interactions were observed (e.g., gait speed). Greater disability was associated with fewer steps and reduced gait speed during community ambulation. In contrast, physical fatigue was correlated with sedentary activity, but was not related to any of the measures of community ambulation gait quality including gait speed. This disparity suggests that more than one mechanism contributes to community ambulation and physical activity in pwMS. Together, these findings demonstrate that during community ambulation, pwMS have marked gait alterations in multiple gait features, reminiscent of dual-task walking measured in the laboratory. Disease-related factors associated with these changes might be targets of rehabilitation.
机译：具有多发性硬化症（PWMS）的人经常遭受步态障碍。在实验室和临床环境中研究了步态的这些变化。然而，缺乏彻底调查社区救护期间的步态变更及其贡献因素。本研究的目的是评估PWMS和健康控制中的群落救护和身体活动，并比较实验室步态到社区救护车。为此，研究了104个受试者：44个PWM和60个健康对照（其年龄与对照相似）。受试者在常用行走和双任务期间在实验室和社区救护期间（1周）期间进行三轴的下背加速度计，以评估活动的数量，类型和质量。结果表明，与健康对照相比，在群落救护中，PWMS少花了更少的步骤，并更慢地走动，具有更大的不对称性和更大的潮流性变异性（P <0.001）。在大多数社区救护过程中的步态速度明显低于实验室通常的步行价值，类似于实验室的双重任务价值。观察到的重要组（PWMS /控制） - 步行条件（实验室/社区示波）相互作用（例如，步态速度）。更大的残疾与较少的步骤相关，并且在社区救护期间减少了步态速度。相比之下，物理疲劳与久坐不动的活动相关，但与包括步态速度的群体救护步态素质的任何措施无关。这种差异表明，不止一种机制有助于PWMS中的社区救护和身体活动。这些研究结果一起表明，在社区救护中，PWMS在多个步态特征中标明了步态改变，让人想起在实验室中测量的双任务行走。与这些变化相关的疾病相关因素可能是康复的目标。

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