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首页> 外文期刊>Journal of neurology >Underlying embolic and pathologic differentiation by cerebral microbleeds in cryptogenic stroke
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Underlying embolic and pathologic differentiation by cerebral microbleeds in cryptogenic stroke

机译：脑脊布在密集脑卒中中的潜在栓塞和病理分化

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Background Cryptogenic stroke encompasses diverse emboligenic mechanisms and pathogeneses. Cerebral microbleeds (CMBs) occur differently among stroke subtypes. The association of CMBs with cryptogenic stroke is essentially unknown. Methods CHALLENGE ESUS/CS (Mechanisms of Embolic Stroke Clarified by Transesophageal Echocardiography for ESUS/CS) is a multicenter registry with comprehensive data including gradient-echo T2*-weighted magnetic resonance imaging of cryptogenic stroke patients who underwent transesophageal echocardiography. Patients' clinical characteristics were compared according to the presence and location of CMBs. Results A total of 661 patients (68.7 +/- 12.7 years; 445 males) were enrolled, and 209 (32%) had CMBs. Age (odds ratio [OR] 1.02, 95% confidence interval [CI] 1.00-1.04, p = 0.020), male sex (OR 1.85, 95% CI 1.18-2.91, p = 0.007), hypertension (OR 1.71, 95% CI 1.03-2.86, p = 0.039), chronic kidney disease (OR 1.64, 95% CI 1.11-2.43, p = 0.013), deep and subcortical white matter hyperintensity (OR 1.82, 95% CI 1.16-2.85, p = 0.009), and periventricular hyperintensity (OR 2.18, 95% CI 1.37-3.46, p = 0.001) were independently associated with the presence of CMBs. Aortic complicated lesions (OR 1.78, 95% CI 1.12-2.84, p = 0.015) were associated with deep and diffuse CMBs, whereas prior anticoagulant therapy (OR 7.88, 95% CI, 1.83-33.9, p = 0.006) was related to lobar CMBs. Conclusions CMBs were common, and age, male sex, hypertension, chronic kidney disease, and cerebral white matter diseases were related to CMBs in cryptogenic stroke. Aortic complicated lesions were associated with deep and diffuse CMBs, while prior anticoagulant therapy was related to lobar CMBs.
机译：背景技术Chryptogenic Stroke包括不同的潜水机制和病原因。中风亚型中的脑微比物（CMBS）发生不同。 CMBs与密码脑卒中的关联基本上是未知的。方法攻击eSUS / CS（eSUS超声心动图澄清的栓塞中风机制）是具有综合数据的多中心注册表，包括梯度回声T2 * -weighted磁共振成像，所述密度脑卒中患者的密码脑卒中患者接受过噬菌学超声心动图。根据CMBS的存在和位置进行比较患者的临床特征。结果共有661名患者（68.7 +/- 12.7岁; 445名男性），209名（32％）有CMBS。年龄（差距[或] 1.02,95％置信区间[CI] 1.00-1.04，P = 0.020），男性（或1.85,95％CI 1.18-2.91，P = 0.007），高血压（或1.71,95％） CI 1.03-2.86，P = 0.039），慢性肾病（或1.64,95％CI 1.11-2.43，P = 0.013），深度和皮质白质超高度（或1.82,95％CI 1.16-2.85，P = 0.009） ，并且疝性超出度（或2.18,95％CI 1.37-3.46，P = 0.001）与CMBS的存在无关。主动脉复杂的病变（或1.78,95％CI 1.12-2.84，P = 0.015）与深和弥漫性CMBS相关，而在抗凝血治疗（或7.88,95％CI，1.83-33.9，P = 0.006）与叶形有关CMBS。结论CMBS是常见的，年龄，男性性，高血压，慢性肾病和脑白质疾病与CICBS中CMBS相关。主动脉复杂的病变与深且漫射CMBS相关，而抗凝血治疗与叶片CMBS有关。

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