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首页> 外文期刊>Journal of neurology >Subjects at risk of Parkinson's disease in health checkup examinees: cross-sectional analysis of baseline data of the NaT-PROBE study
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Subjects at risk of Parkinson's disease in health checkup examinees: cross-sectional analysis of baseline data of the NaT-PROBE study

机译：帕金森病风险的受试者在健康检查中的疾病：NAT探针研究的基线数据的横截面分析

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Introduction The present study aimed to survey the prevalence of prodromal symptoms of Parkinson's disease (PD) in Japanese health checkup examinees, for identifying at-risk subjects. Methods We conducted a questionnaire survey of annual health checkup examinees without neurological symptoms using the following self-reported questionnaires: Japanese version of the Scale for Outcomes in Parkinson's disease for Autonomic Symptoms (SCOPA-AUT); Self-administered Odor Question (SAOQ); REM Sleep Behavior Disorder Screening Scale (RBDSQ); Beck Depression Inventory-Second Edition (BDI-II); Epworth Sleepiness Scale (ESS); and Physical Activity Scale for the Elderly (PASE). The presence of prodromal symptoms was determined using the 90th percentile threshold of each questionnaire. Subjects >= 50 years of age with >= 2 core prodromal symptoms (dysautonomia, hyposmia, and RBD), were classified as at risk. Results Between March 2017 and March 2018, 4,953 participants sufficiently answered the questionnaires. Among 2,726 subjects >= 50 years of age, 155 were classified as at risk. These subjects had worse values of BDI-II (12.0 +/- 8.3 vs. 4.4 +/- 3.8, p < 0.001) and ESS (9.6 +/- 5.0 vs. 6.3 +/- 3.2, p < 0.001), in addition to SCOPA-AUT, SAOQ, and RBDSQ. Male at-risk subjects showed lower values of hemoglobin (14.8 +/- 1.3 vs. 15.0 +/- 1.1, p = 0.032) and low density lipoprotein cholesterol (114.5 +/- 30.3 vs. 123.0 +/- 28.9, p = 0.004) than the examinees reporting no prodromal symptoms. Conclusion Approximately 6% of the population aged 50 years or older was at risk for PD. Male at-risk subjects had mild hematological and metabolic changes relevant to PD.
机译：引言本研究旨在调查日本健康检查考生中帕金森病（PD）的前驱症状的患病率，用于识别风险受试者。方法采用下列自我报告的问卷进行了无神经系统症状的年卫生检查考生的调查问卷调查：帕金森疾病中的日本版本为自主主义症状（SCOPA-AUT）;自我管理的气味问题（SAOQ）; REM睡眠行为障碍筛查量表（RBDSQ）; Beck抑郁症库存第二版（BDI-II）; Epworth Sleepiness Scale（ESS）;老年人（Pase）的身体活动量表。使用每个问卷的第90百分位阈值确定前驱症状的存在。受试者> = 50岁以下，= 2核心前驱症状（患有DysoOdoMia，Hyposmia和RBD）被归类为风险。结果2017年3月至2018年3月，4,953名参与者充分回答了问卷。在2,726名受试者中> = 50岁，155名被归类为风险。此外，这些受试者的BDI-II值较差的BDI-II值（12.0 +/- 8.3，P <0.001）和ESS（9.6 +/- 5.0和6.3 +/- 3.2，p <0.001）， to scopa-aut，saoq和rbdsq。雄性风险受试者显示出较低的血红蛋白值（14.8 +/- 1.3对15.0 +/- 1.1，p = 0.032）和低密度脂蛋白胆固醇（114.5 +/- 30.3与123.0 +/- 28.9，p = 0.004 ）比考生报告没有前驱症状。结论50岁或以上的人口约6％面临Pd的风险。男性风险受试者具有温和的血液学和代谢变化与PD相关。

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