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首页> 外文期刊>Journal of neurology >A longitudinal study of cognitive function in multiple sclerosis: is decline inevitable?
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A longitudinal study of cognitive function in multiple sclerosis: is decline inevitable?

机译：多发性硬化症中认知功能的纵向研究：是不可避免的下降吗？

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Background Numerous cross-sectional studies report cognitive impairment in multiple sclerosis (MS), but longitudinal studies with sufficiently long-term follow-up are scarce. Objective We aimed to investigate the cognitive 10-year course of a cohort of MS patients. Methods 59 patients with clinically isolated syndrome (CIS) or relapsing-remitting (RR) MS were evaluated with Rao's Brief Repeatable Battery of Neuropsychological Tests at baseline and follow-up (at least 10 years later). They constituted 47.2% of 124 consecutive CIS and RRMS patients originally evaluated at baseline. Patients assessed at follow-up were well matched for baseline clinical characteristics with dropouts. Results The proportion of MS patients with overall cognitive impairment was increased by 10% within the 10-year period. When grouped on the basis of impairment in specific cognitive domains at baseline, patients originally impaired showed improvement at follow-up, while the opposite trend was observed for patients non-impaired at first assessment. A detailed case-by-case investigation revealed mixed evolution patterns, several patients fail in fewer domains at follow-up compared to baseline or failing at different domains at follow-up compared to baseline. Conclusions This study suggests a more fluid picture for the evolution of cognitive function in a subgroup of MS patients and contradicts the concept of an inevitable, progressively evolving "dementia".
机译：背景技术许多横截面研究报告了多发性硬化症（MS）中的认知障碍，但具有足够长期随访的纵向研究是稀缺的。目的我们旨在调查MS患者队列的认知10年课程。方法用RAO在基线和后续随访（至少10年后）评估59例临床上综合征（CIS）或复发延迟（RR）MS的患者。它们组成了124％的124％的CIS和RRMS患者最初在基线评估的患者。在随访中评估的患者对基线临床特征进行了很好的匹配，辍学。结果10年期内，患有整体认知障碍的MS患者的比例增加了10％。当基于基线的特异性认知结构域的损伤进行分组时，患者最初受损表现出随访的改善，而在第一次评估中非受损的患者观察到相反的趋势。一个详细的逐个案例调查显示了混合演化模式，几个患者在随访的域中失败，与基线相比或在随访的不同域比与基线相比失败。结论本研究表明，对于MS患者的亚组中的认知功能的演变，提出了一种更流体的图像，并与不可避免的逐步发展的“痴呆症”相矛盾。

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