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首页> 外文期刊>Journal of neurology >Discontinuation of teriflunomide and dimethyl fumarate in a large Italian multicentre population: a 24-month real-world experience
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Discontinuation of teriflunomide and dimethyl fumarate in a large Italian multicentre population: a 24-month real-world experience

机译：在大型意大利人群中停止了Teriflunomide和二甲基富马酸酯：24个月的真实体验

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BackgroundTeriflunomide (TRF) and Dimethyl fumarate (DMF) are licensed drugs for relapsing-remitting Multiple Sclerosis (RRMS).ObjectivesWe aimed to compare the rate and the time to discontinuation among persons with RRMS (pwRRMS), newly treated with TRF and DMF.Materials and methodsA retrospective study on prospectively collected data was performed in nine tertiary MS centers, in Italy. The 24-month discontinuation rate in the two cohorts was the primary study outcome. We also assessed the time to discontinuation and reasons of therapy withdrawn. Discontinuation of TRF and DMF was defined as a gap of treatment60 days.ResultsA cohort of 903 pwRRMS (316 on TRF and 587 on DMF) was analyzed. During 24 months of follow-up, pwRRMS on TRF and DMF showed similar discontinuation rates. The analysis of predictors with Cox regression model showed differences between the two groups (p for log-rank test=0.007); male gender [HR 2.21 (1.00-4.90); p=0.01] and the number of previous switches [HR 1.47 (1.16-1.86); p=0.01] were associated with higher hazard of discontinuation in the DMF group.ConclusionsIn a real-world setting, pwRRMS on TRF and DMF had similar discontinuation rates over 24 months. Male pwRRMS on DMF with a previous history of therapeutic failure are at more risk of discontinuation therapy.
机译：LafactureTeriflunomide（TRF）和富马酸二甲烷（DMF）是用于复发延迟多发性硬化症（RRMS）的许可药物.bjectiveswe，旨在比较RRMS（PWRRMS）的人群中停止的速率和时间，用TRF和DMF.MARTIALEM。方法在意大利的九个第三节MS中心进行了对预期收集的数据的回顾性研究。两位队列中的24个月停产率是主要的研究结果。我们还评估了停止的时间和治疗撤回的原因。分析了TRF和DMF的中断被定义为治疗方法60天。分析了903个PWRRMS（TRF和DMF上的316件）的队列队列。在24个月的后续后，TRF和DMF上的PWRRMS显示出类似的停止率。具有Cox回归模型的预测因子的分析显示了两组之间的差异（对逻辑秩检验的p = 0.007）;男性性别[HR 2.21（1.00-4.90）; p = 0.01]和先前交换机的数量[HR 1.47（1.16-1.86）; P = 0.01]与DMF组中的中断危害较高有关。结论真实世界的环境，TRF和DMF上的PWRRMS在24个月内具有类似的停止率。 DMF的雄性PWRRMS与先前治疗失败历史的风险更多。

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