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首页> 外文期刊>Journal of neurology >The outcome of acute functional neurological disorder: a meta-analysis of stroke-mimic presentations
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The outcome of acute functional neurological disorder: a meta-analysis of stroke-mimic presentations

机译：急性功能性神经障碍的结果：中风模拟介绍的荟萃分析

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Objective The prognosis of motor functional neurological disorder (FND) is considered poor; however, all data come from chronic cohorts collected by specialists. The aim of this study was to determine the clinical outcome of acute FND, captured as 'stroke-mimics'. Methods A meta-analysis of studies with outcome data on functional stroke mimics. Authors were contacted to provide more information on their FND mimics, including baseline, discharge and follow-up stroke scales. A random effects meta-analysis of proportion of 'good outcome' was the primary measure of interest, with additional descriptive and statistical analysis. 'Good outcome' employed the usual conventions of modified Rankin Score (mRS) or National Institutes of Health Stroke Scale (NIHSS) <= 1. Results Eight studies with 79 patients were identified and analysed, all of cohorts undergoing thrombolysis. The mean age at presentation was 49.7 years with a 62% female preponderance, and median NIHSS score of 4. The proportion of patients with mRS or NIHSS <= 1 changed significantly from admission to discharge or follow up [from 24 (30%) to 50 (63%), p < 0.001]. Meta-analysis of the synthesized data showed the pooled standardized mean change (SMC) was statistically significant (SMC = - 1.28, [95% CI = -2.25, - 0.30], p = 0.010) indicating good symptomatic outcome for acute FND patients presenting as stroke-mimics. Heterogeneity was large. Conclusion Patients presenting with acute motor FND have good outcome of their presenting symptoms by discharge and at follow-up, following thrombolysis for presumed stroke, in contrast to specialist cohorts. Demographic differences, in addition to the thrombolysis, are possible explanations for these more favourable results.
机译：目的认为运动功能神经障碍（FND）的预后被认为是穷人;然而，所有数据都来自专家收集的慢性队列。本研究的目的是确定急性FND的临床结果，捕获“中风模仿”。方法对功能性冲程模拟的结果数据进行研究。联系了作者，提供有关其FND模仿的更多信息，包括基线，放电和随访中风尺度。随机效应Meta分析“良好结果”的比例是兴趣的主要衡量标准，具有额外的描述性和统计分析。 “良好的结果”雇用了经常公约的改进的Rankin得分（MRS）或国立卫生卒中量表（NIHSS）<= 1.结果鉴定并分析了79名患者的八项研究，所有群体接受溶栓溶解。介绍的平均年龄为49.7岁，女性优势62％，中位数NIHSS得分为4.患者或NIHSS <= 1的患者比例显着改变，从入场发出或跟进[从24（30％） 50（63％），p <0.001]。合成数据的META分析显示汇总标准化平均变化（SMC）是统计学意义的（SMC = - 1.28，[95％CI = -2.25， - 0.30]，P = 0.010），表明急性FND患者呈现出良好的症状结果作为中风模仿。异质性大。结论患者患有急性电机FND的患者通过排放和随访具有良好的结果，并在推定中风溶栓后，与专家队列相反。除了溶栓外，人口统计学差异也可能对这些更有利的结果进行解释。

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