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首页> 外文期刊>Journal of neurology >Papilloedema is an independent prognostic factor for POEMS syndrome
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Papilloedema is an independent prognostic factor for POEMS syndrome

机译：Papilloedema是诗歌综合征的独立预后因素

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摘要

POEMS syndrome is a potentially fatal disease, and prediction of prognostic factors for POEMS syndrome is important for clinicians. Papilloedema is an early sign of the syndrome. The present study was carried out to evaluate whether papilloedema is a prognostic factor for POEMS syndrome. Between January 2003 and December 2012, 94 patients with POEMS syndrome were enrolled in this study. The patients were divided into groups with and without papilloedema. Logistic regression was performed to identify risk factors related to papilloedema. Prognostic factors were analysed with Cox proportional hazard regressions for POEMS syndrome-related prognoses, and survival curves were plotted using the Kaplan-Meier method and compared by the log-rank test. Papilloedema was found in 52.1 % of the patients with POEMS syndrome. Raised intracranial pressure [hazard ratio (HR) 3.06, 95 % confidence interval (CI) 1.24-7.41; P = 0.011] and elevated cerebrospinal fluid protein levels (HR 2.03, 95 % CI 1.07-4.51; P = 0.043) were independently associated with papilloedema. Papilloedema, decreased diffusing capacity of the lung for carbon monoxide (DLCO) and treatment with corticosteroids alone were related to poor prognosis in POEMS syndrome. In multivariate analysis, papilloedema (HR 1.58, 95 % CI 1.05-2.46; p = 0.027) and decreased DLCO (HR 2.17, 95 % CI 1.12-3.39; p — 0.023) were independent factors for POEMS syndrome-related death. Papilloedema and decreased DLCO are important prognostic factors for patients with POEMS syndrome, which can help clinicians predict the risk of mortality and provide better medical care for these patients.
机译：诗歌综合征是一种潜在的致命疾病，并且对诗歌综合征的预后因素预测对临床医生很重要。 Papilloedema是综合症的早期迹象。进行本研究以评估乳头肺肿块是否是诗歌综合征的预后因素。 2003年1月至2012年12月，94例诗歌综合征患者参加本研究。患者分为含有乳头细胺的群体。进行逻辑回归以识别与乳头乳乳酪相关的风险因素。通过Cox比例危害回归分析预后因素对诗综合征相关的预后，并使用Kaplan-Meier方法绘制生存曲线，并通过对数级测试进行比较。在诗歌综合征患者的52.1％中发现了papilloedema。提高颅内压力[危害比（HR）3.06,95％置信区间（CI）1.24-7.41; P = 0.011]和升高的脑脊液蛋白水平（HR 2.03,95％CI 1.07-4.51; P = 0.043）与乳头乳乳乳肿瘤独立相关。乳头乳乳酪，降低肺部的肺部（DLCO）的扩散能力，并且单独用皮质类固醇治疗与诗歌综合征的预后不良有关。在多变量分析中，乳头乳酪（HR 1.58,95％CI 1.05-2.46; P = 0.027）和DLCO降低（HR 2.17,95％CI 1.12-3.39; P - 0.023）是诗综合征相关死亡的独立因素。乳头乳酪和DLCO减少是诗歌综合征患者的重要预后因素，可以帮助临床医生预测死亡率，并为这些患者提供更好的医疗保健。

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