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首页> 外文期刊>Journal of neurology >Long-term outcomes of epilepsy surgery in tuberous sclerosis complex
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Long-term outcomes of epilepsy surgery in tuberous sclerosis complex

机译：结核硬化症复合体的癫痫手术的长期结果

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Approximately 50% of patients with tuberous sclerosis complex (TSC) present intractable epilepsy, and surgery is an option for those patients. Hereby, we analyze long-term seizure control and neuropsychological outcomes of epilepsy surgery in patients with TSC. Clinical data were retrospectively collected from 66 patients with TSC and epilepsy followed up over 5 years, 51 of whom underwent epilepsy surgery between 2001 and 2011. Reductions in the number of seizures were analyzed at 1-year (1FU), 5-year (5FU), and 10-year (10FU) follow-ups visits after the operation. Influential factors on postoperative seizure free and intelligence quotient (IQ) and quality-of-life (QOL) outcomes were evaluated at 5FU. Resective procedures included 26 tuber resections, 15 lobectomies, and 10 tuber resections and lobectomies. Corpus callosotomies were performed as the adjunctive approach in 11 cases with low IQ. The percentages of seizure-free cases were 74.5% at 1FU, 58.8% at 5FU, and 47.8% at 10FU, and the predictive factor for long-term postoperative seizure freedom was the history of preoperative seizures and preoperative full-scale IQ. Significant improvements were found in performance IQ, full-scale IQ, and QOL in patients from the surgery group, particularly those who were seizure free after the operation. Our study showed that epilepsy surgery in TSC with epilepsy rendered improvements in seizure control, full-scale IQ, and QOL. Satisfactory long-term seizure control was often achieved with an early operation and without mental retardation, and improvements in QOL and IQ were frequently observed in postoperative patients who remained seizure free.
机译：大约50％的患有结核硬化症复合体（TSC）的患者目前顽固的癫痫，手术是那些患者的选择。在此，我们分析TSC患者的癫痫手术的长期癫痫发作控制和神经心理学结果。回顾性从66例TSC和癫痫患者中收集临床资料，随访5年来，51名，其中51名在2001年至2011年期间接受癫痫手术。在1年（1FU），5年（5FU）中分析了缉获量的减少（5FU ）和运作后10年（10FU）的后续访问。在5FU评估了术后癫痫发作的影响因素和智力侦察（IQ）和寿命质量（QOL）结果。敏锐程序包括26个块茎切除，15只曲塞和10个块茎切除术和肺切除术。胼insoROSOTOMIES作为11例患者的辅助方法进行。无癫痫病例的百分比在1倍的含量为74.5％，5Fu的58.8％，10Fu的47.8％，长期术后癫痫发作自由的预测因素是术前癫痫发作和术前全规模智商的历史。在手术组患者的表现智商，全规模智商和QoL中发现了显着的改善，特别是那些在手术后自由癫痫发作的患者。我们的研究表明，TSC的癫痫手术与癫痫，癫痫发作，全面智商和QOL的改进。令人满意的长期癫痫管道通常通过早期操作而没有精神延迟，并且在术后患者中经常观察到QoL和IQ的改进，仍然癫痫发作。

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