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首页> 外文期刊>Journal of neurology >High-intensity interval training in facioscapulohumeral muscular dystrophy type 1: a randomized clinical trial
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High-intensity interval training in facioscapulohumeral muscular dystrophy type 1: a randomized clinical trial

机译：面部型肌肉营养不良型患者高强度间隔训练1型：随机临床试验

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Increasing evidence suggests that high-intensity training (HIT) is a time-efficient exercise strategy to improve fitness. HIT has never been explored in neuromuscular diseases, likely because it may seem counterintuitive. A single session of high-intensity exercise has been studied without signs of muscle damage in facioscapulohumeral muscular dystrophy type 1 (FSHD1). We aimed to determine whether HIT is safe and effective in FSHD1 in a randomized, controlled parallel study. Untrained adults with genetically verified FSHD1 (n = 13) able to perform cycle-ergometer exercise were randomized to 8 weeks of supervised HIT (n = 6) (3 x 10-min cycle-ergometer-HIT/week) or 8 weeks of usual care (n = 7). Following this, all participants performed 8 weeks of unsupervised HIT (3 x 10-min cycle-ergometer-HIT/week). Primary outcome was fitness, maximal oxygen uptake/min/kg body weight. Furthermore, workload, 6-min walk distance, 5-time sit-to-stand time, muscle strength, and daily activity levels were measured. Pain, fatigue, and plasma-CK were monitored. Twelve patients completed the randomized part of the study. Plasma-CK levels and pain scores were unaffected by HIT. Supervised HIT improved fitness (3.3 ml O-2/min/kg, CI 1.2-5.5, P < 0.01, n = 6, NNT = 1.4). Unsupervised HIT also improved fitness (2.0 ml O-2/min/kg, CI 0.1-3.9, P = 0.04, n = 4). There was no training effect on other outcomes. Patients preferred HIT over strength and moderate-intensity aerobic training. It may seem counterintuitive to perform HIT in muscular dystrophies, but this RCT shows that regular HIT is safe, efficacious, and well liked by moderately affected patients with FSHD1, which suggests that HIT is a feasible method for rehabilitating patients with FSHD1.
机译：越来越多的证据表明，高强度培训（命中）是一种有效的运动策略，以提高健身。击中从未在神经肌肉疾病中探索过，可能是因为它看起来令人反对。已经研究了一系列高强度运动，没有面部肌肉营养不良型1型（FSHD1）中的肌肉损伤迹象。我们旨在确定在随机，受控的并行研究中是否在FSHD1中判断是否安全有效。具有遗传验证的FSHD1（n = 13）的未经训练的成年人能够进行循环钻头锻炼，被随机调至6周的监督击中（n = 6）（3 x 10分钟 - 仲裁仪撞击/周）或通常的8周护理（n = 7）。在此之后，所有参与者都执行了8周的无人监督的击中（3 x 10分钟的循环计数器撞击/周）。主要结果是健身，最大氧吸收/ min / kg体重。此外，测量工作负载，6分钟步行距离，5次位于静止时间，肌肉力量和日常活性水平。监测疼痛，疲劳和血浆CK。 12名患者完成了研究的随机部分。血浆-CK水平和疼痛分数不受击中的影响。受监管的健身（3.3ml O-2 / min / kg，CI 1.2-5.5，P <0.01，n = 6，NNT = 1.4）。无监督的抗击也改善了健身（2.0mL O-2 / min / kg，CI 0.1-3.9，P = 0.04，n = 4）。没有关于其他结果的培训效果。患者优先于强度和中等强度的有氧训练。在肌营养不监药物中遭受遭受令人行应的是令人行应的，但这种RCT表明，经常击中是安全，有效的，并且受到适度影响的FSHD1患者的安全性，这表明受到了恢复FSHD1患者的可行方法。

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