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首页> 外文期刊>Journal of neurology >Japanese encephalitis can trigger anti-N-methyl-D-aspartate receptor encephalitis
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Japanese encephalitis can trigger anti-N-methyl-D-aspartate receptor encephalitis

机译：日本脑炎可以触发抗N-甲基-D-天冬氨酸受体脑炎

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摘要

Japanese encephalitis (JE) is usually a monophasic disease; however, in rare cases, patients with JE may have an early relapse after a partial recovery, giving rise to a biphasic pattern for the disease. In this study, we report three pediatric cases in which post-JE relapse was characterized by movement disorder and/or behavioral problems, and was related to anti-N-methyl-D-aspartate receptor (NMDAR) immunoglobulin G (IgG). Serum and cerebrospinal fluid were examined for anti-NMDAR IgG in three patients who had confirmed JE and then developed relapsing symptoms which were similar to those of anti-NMDAR encephalitis. The main symptoms of the two young children were choreoathetosis, irritability, and sleep disorder; while for the teenager, agitation, mutism, rigidity, and sleep disorder were the main symptoms. Samples of cerebrospinal fluid from all patients were positive for anti-NMDAR IgG, and all patients gradually improved with immunotherapy. Testing for NMDAR antibodies is highly recommend in patients with JE, especially those with a relapsing syndrome involving movement disorder and/or behavioral problems, as these patients may benefit from immunotherapy.
机译：日本脑炎（JE）通常是单表疾病;然而，在极少数情况下，患者在部分恢复后可能会早期复发，从而产生疾病的双色模式。在这项研究中，我们报告了三种儿科病例，其特征在于运动障碍和/或行为问题，其特征在于运动障碍和/或行为问题，与抗N-甲基-D-天冬氨酸受体（NMDAR）免疫球蛋白G（IgG）有关。在已经确认JE的患者中检查血清和脑脊髓液中的抗NMDAR IgG，然后开发出类似于抗NMDAR脑炎的症状。两只幼儿的主要症状是思科病变，烦躁和睡眠障碍;虽然为少年，搅拌，突变，刚性和睡眠障碍是主要的症状。来自所有患者的脑脊液样本对于抗NMDAR IgG阳性，所有患者均逐渐改善免疫疗法。 JE患者强烈推荐对NMDAR抗体的测试，特别是那些涉及移动障碍和/或行为问题的复发综合症，因为这些患者可能受益于免疫疗法。

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