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首页> 外文期刊>Journal of neurology >Burden of herpes simplex virus encephalitis in the United States
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Burden of herpes simplex virus encephalitis in the United States

机译：疱疹病毒脑炎在美国的负担

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Herpes simplex virus encephalitis (HSVE) is a disease of public health concern, but its burden on the healthcare of United States has not been adequately assessed recently. We aimed to define the incidence, complications and outcomes of HSVE in the recent decade by analyzing data from a nationally representative database. Healthcare Cost and Utilization Project databases were utilized to identify patients with primary discharge diagnosis of HSVE. Annual hospitalization rate was estimated and several preselected inpatient complications were identified. Regression analyses were used to identify mortality predictors. Key epidemiological factors were compared with those from other countries. Total 4871 patients of HSVE were included in our study. The annual hospitalization rate was 10.3 +/- 2.2 cases/million in neonates, 2.4 +/- 0.3 cases/million in children and 6.4 +/- 0.4 cases/million in adults. Median age was 57 years and male:female incidence ratio was 1:1. Rates of some central nervous system complications were seizures (38.4%), status epilepticus (5.5%), acute respiratory failure (20.1%), ischemic stroke (5.6%) and intracranial hemorrhage (2.7%), all of which were significantly associated with mortality. In-hospital mortality in neonates, children and adults were 6.9, 1.2 and 7.7%, respectively. HSVE still remains a potentially lethal infectious disease with high morbidity and mortality. Most recent epidemiological data in this study may help understanding this public health disease, and the patient outcome data may have prognostic significance.
机译：单纯疱疹病毒脑炎（HSVE）是一种公共卫生疾病的关注，但它最近没有充分评估美国医疗保健的负担。我们旨在通过分析来自国家代表性数据库的数据来定义最近十年的发病率，并发症和结果。医疗保健成本和利用项目数据库用于鉴定HSVe初级放电诊断的患者。估计年度住院率估计，并确定了几种预选的住院患者并发症。回归分析用于识别死亡率预测因子。与其他国家的重点流行病学因素进行了比较。我们的研究中包含4871名HSV患者。每年住院率为10.3 +/- 2.2患者/百万患者，2.4 +/- 0.3患者/百万儿童和6.4 +/- 0.4患者/百万人。中位年龄为57岁，男性：女性发病率为1：1。一些中枢神经系统并发症的速率是癫痫发作（38.4％），状态癫痫症（5.5％），急性呼吸衰竭（20.1％），缺血性卒中（5.6％）和颅内出血（2.7％），所有这些都与之显着相关死亡。新生儿，儿童和成人的住院死亡率分别为6.9,1.2和7.7％。 Hsve仍然是一种潜在的致命传染病，发病率高，死亡率高。本研究中最近的流行病学数据可能有助于理解这种公共卫生疾病，患者结果数据可能具有预后意义。

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