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首页> 外文期刊>Journal of neurology >Cognitive dysfunction in adult patients with neuromyelitis optica: a systematic review and meta-analysis
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Cognitive dysfunction in adult patients with neuromyelitis optica: a systematic review and meta-analysis

机译：神经髓炎术患者的认知功能障碍OPTICA：系统评价和荟萃分析

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摘要

The objective of this study was to investigate cognitive dysfunction in 24-60-year-old neuromyelitis optica (NMO) patients, demographically matched healthy subjects, and MS patients. We conducted a comprehensive literature review of the PubMed, Medline, EMBASE, CNKI, Wan Fang Date, Web of Science, and Cochrane Library databases from inception to May 2016 for case-control studies that reported cognitive test scores in NMO patients, healthy subjects, and MS patients. Outcome measures were cognitive function evaluations, including performance on attention, language, memory, information processing speed, and executive function tests. The meta-analysis included eight studies. NMO patients performed significantly worse on attention (P < 0.00001), language (P = 0.00008), memory (P = 0.00004), information processing speed (P < 0.00001), and executive function tests (P = 0.00009) than healthy subjects. There were no significant differences in performance between NMO patients and MS patients on these tests. This meta-analysis indicates that NMO patients aged 24-60 years have significantly worse cognitive performance than demographically matched healthy subjects. However, this was comparable to the performance of demographically matched MS patients. There is a need for further rigorous randomized controlled trials with focus on elucidating the underlying mechanism of cognitive dysfunction in NMO patients.
机译：本研究的目的是调查24-60岁的神经髓炎OPTICA（NMO）患者，人群匹配的健康受试者和MS患者的认知功能障碍。我们对PubMed，Medline，Embase，CNKI，WAN F型日期，科学网络以及Cochrane图书馆数据库进行了全面的文献综述，从2016年5月开始，案例控制研究报告了NMO患者的认知测试评分，健康受试者，和女士患者。结果措施是认知函数评估，包括关注，语言，内存，信息处理速度和执行功能测试的性能。 Meta分析包括八项研究。 NMO患者对注意性显着更差（P <0.00001），语言（P = 0.00008），内存（P = 0.00004），信息处理速度（P <0.00001），和执行功能测试（P = 0.00009），而不是健康的受试者。 NMO患者与MS患者之间的性能没有显着差异。该荟萃分析表明，24-60岁的NMO患者具有比人群匹配的健康受试者的认知性能显着差。然而，这与人群匹配的MS患者的表现相当。需要进一步严格的随机对照试验，重点是阐明NMO​​患者的认知功能障碍的潜在机制。

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  • 来源
    《Journal of neurology》 |2017年第8期|共10页
  • 作者

    Meng Hao; Xu Jun; Pan Chenling; Cheng Jiaxing; Hu Yue; Hong Yin; Shen Yuehai; Dai Hua;

  • 作者单位

    Yangzhou Univ Noncoding RNA Ctr Coll Med Yangzhou 225001 Jiangsu Peoples R China;

    Northern Jiangsu Peoples Hosp Dept Neurol Yangzhou 225001 Jiangsu Peoples R China;

    Kunming Univ Sci &

    Technol Fac Life Sci &

    Technol Kunming 650500 Yunnan Peoples R China;

    Northern Jiangsu Peoples Hosp Dept Neurol Yangzhou 225001 Jiangsu Peoples R China;

    Northern Jiangsu Peoples Hosp Dept Neurol Yangzhou 225001 Jiangsu Peoples R China;

    Northern Jiangsu Poeples Hosp Hlth Management Ctr Yangzhou 225001 Jiangsu Peoples R China;

    Kunming Univ Sci &

    Technol Fac Life Sci &

    Technol Kunming 650500 Yunnan Peoples R China;

    Yangzhou Univ Noncoding RNA Ctr Coll Med Yangzhou 225001 Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

    Cognitive dysfunction; Neuromyelitis optica; Multiple sclerosis; Meta-analysis;

    机译：认知功能障碍;神经髓炎OPTICA;多发性硬化;META分析;

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