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首页> 外文期刊>Journal of neurology >Biomechanical response of the CNS is associated with frailty in NPH-suspected patients
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Biomechanical response of the CNS is associated with frailty in NPH-suspected patients

机译：CNS的生物力学响应与NPH可疑患者的脆弱相关

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摘要

Frailty is known to predict dementia. However, its link with neurodegenerative alterations of the central nervous system (CNS) is not well understood at present. We investigated the association between the biomechanical response of the CNS and frailty in older adults suspected of normal pressure hydrocephalus (NPH) presenting with markers of multiple co-existing pathologies. The biomechanical response of the CNS was characterized by the CNS elastance coefficient inferred from phase contrast magnetic resonance imaging and intracranial pressure monitoring during a lumbar infusion test. Frailty was assessed with an index of health deficit accumulation. We found a significant association between the CNS elastance coefficient and frailty, with an effect size comparable to that between frailty and age, the latter being the strongest known risk factor for frailty. Results were independent of CSF dynamics, showing that they are not specific to the NPH neuropathological condition. The CNS biomechanical characterization may help to understand how frailty is related to neurodegeneration and detect the shift from normal to pathological brain ageing.
机译：令人害怕的是预测痴呆症的脆弱。然而，目前，它与中枢神经系统（CNS）的神经变性改变的联系尚不清楚。我们调查了涉嫌常规压力脑积水（NPH）的老年人CNS和脆弱的生物力学响应与呈现多种共存病理学的标志物的关系。 CNS的生物力学响应的特征在于腰椎输注试验期间从相腺磁共振成像和颅内压力监测推断的CNS弹性系数。通过卫生赤字积累指数评估脆弱。我们在CNS弹性系数和脆弱之间发现了一个重要的关联，其效果尺寸与体弱和年龄之间相当，后者是最强烈的脆弱危险因素。结果与CSF动态无关，表明它们不特异于NPH神经病理病症。 CNS生物力学表征可有助于了解脆弱与神经变性相关的脆弱，并检测从正常到病理脑老化的变化。

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