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首页> 外文期刊>Journal of neurology >Pre-treatment cerebral microbleeds and intracranial hemorrhage in patients with ischemic stroke receiving endovascular therapy: a systematic review and meta-analysis
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Pre-treatment cerebral microbleeds and intracranial hemorrhage in patients with ischemic stroke receiving endovascular therapy: a systematic review and meta-analysis

机译：缺血性卒中接受血管内疗法患者的预处理脑微微术和颅内出血：系统审查和荟萃分析

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Background and purpose Predicting the risk of intracranial hemorrhage (ICH) is an important aspect for improving the efficacy and safety of endovascular therapy (EVT). We intended to perform a systematic review and meta-analysis to show whether pre-treatment cerebral microbleeds (CMBs) were associated with an increased incidence of ICH in patients with ischemic stroke receiving EVT. Methods We searched PubMed, EMBASE, Web of Science and Cochrane Library from their dates of inception to December 18, 2018, and also manually searched reference lists of relevant articles. Cumulative prevalence of CMBs and ICH was calculated. Relative risk and 95% confidence interval (CI) were calculated for the incidence of ICH in patients with CMBs versus those without after EVT. Results Four studies involving 598 patients were included. The pooled prevalence of CMBs was 18% (95% CI 15-21%) and the pooled prevalence of >= 5 CMBs was 1% (95% CI 0-2%). The pooled incidence of ICH was 29% (95% CI 8-49%) in all patients, 25% (95% CI 5-45%) in those with CMBs and 29% (95% CI 8-50%) in those without CMBs. The pooled relative risk of ICH was 0.90 (95% CI 0.65-1.25, P = 0.528; I-2 = 0%, P = 0.949) in patients with CMBs versus those without CMBs. Conclusions There is no evidence that pre-treatment CMBs were associated with an increased incidence of ICH in patients with ischemic stroke receiving EVT.
机译：预测颅内出血风险（ICH）的背景和目的是提高血管内疗法（EVT）的疗效和安全性的一个重要方面。我们旨在进行系统评价和荟萃分析，以展示预处理的脑显微化（CMBS）是否与缺血性卒中患者接受EVT的患者的发病率增加有关。方法从2018年12月18日开始搜索Pubmed，Embase，科技和Cochrane图书馆的PubMed，Embase，Cochrane图书馆，也可以手动搜索相关文章的参考列表。计算CMBS和ICH的累积患病率。相对风险和95％置信区间（CI）计算了CMBS与EVT后的CMBS与那些人的ICH的发病率。结果包括涉及598名患者的四项研究。 CMBS的汇集患病率为18％（95％CI 15-21％），汇集率> = 5 cmbs为1％（95％CI 0-2％）。所有患者的汇集发病率为29％（95％CI 8-49％），其中25％（95％CI 5-45％），其中CMBS和29％（95％CI 8-50％）没有cmbs。 CMBS与没有CMBS的CMBS与那些没有CMBS的CMBS与那些人的患者，富含ICH的相对风险为0.90（95％CI 0.65-1.25，P = 0.528），P = 0.949）。结论没有证据表明，预处理的CMBS与缺血性中风接受EVT的患者的ICH发病率增加有关。

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