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首页> 外文期刊>Journal of orthopaedic research >Joint contracture is reduced by intra-articular implantation of rosiglitazone-loaded hydrogels in a rabbit model of arthrofibrosis
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Joint contracture is reduced by intra-articular implantation of rosiglitazone-loaded hydrogels in a rabbit model of arthrofibrosis

机译：通过关节内植入罗格列酮负载的水凝胶在兔模型中的关节内植入细胞植入的关节挛缩

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Trauma, surgery, and other inflammatory conditions can lead to debilitating joint contractures. Adjunct pharmacologic modalities may permit clinical prevention and treatment of recalcitrant joint contractures. We investigated the therapeutic potential of rosiglitazone by intra-articular delivery via oligo[poly(ethylene glycol)fumarate] (OPF) hydrogels in an established rabbit model of arthrofibrosis. OPF hydrogels loaded with rosiglitazone were characterized for drug elution properties upon soaking in minimum essential media (MEM) with 10% fetal bovine serum and measurements of drug concentrations via High Performance Liquid Chromatography (HPLC). Drug-loaded scaffolds were surgically implanted into 24 skeletally mature female New Zealand White rabbits that were divided into equal groups receiving OPF hydrogels loaded with rosiglitazone (1.67 mg), or vehicle control (10 mu l DMSO). After 8 weeks of joint immobilization, rabbits were allowed unrestricted cage activity for 16 weeks. Contracture angles of rabbit limbs treated with rosiglitazone showed statistically significant improvements in flexion compared to control animals (mean angles, respectively, 64.4 degrees vs. 53.3 degrees, p 0.03). At time of sacrifice (week 24), animals in the rosiglitazone group continued to exhibit less joint contracture than controls (119.0 degrees vs. 99.5 degrees, p = 0.014). The intra-articular delivery of rosiglitazone using implanted OPF hydrogels decreases flexion contractures in a rabbit model of arthrofibrosis without causing adverse effects (e.g., gross inflammation or arthritis). Statement of Clinical Significance: Post-traumatic joint contractures are common and debilitating, with limited available treatment options. Pharmacologic interventions can potentially prevent and treat such contractures. This study is translational in that a commercially approved medication has been repurposed through a novel delivery device. (c) 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2949-2955, 2018.
机译：创伤，手术和其他炎症条件可能导致衰弱的关节挛缩。兼职药理学模式可允许临床预防和治疗顽固性关节挛缩。我们通过寡核苷酸寡核苷酸的兔模型中的寡核苷酸含有寡核苷酸的兔模型中的关节内递送来研究Rosiglitazone的治疗潜力。用罗庚唑酮负载的OPF水凝胶，其特征在于浸泡在最小必需培养基（MEM）中浸泡10％胎牛血清和通过高效液相色谱（HPLC）测量药物浓度的药物洗脱性能。将药物上的支架手术植入到24个骨骼成熟的雌性新西兰白兔中，分为接受罗格列酮（1.67mg）的OPF水凝胶或载体对照（10μlDMSO）的opf水凝胶。在连续8周的共同化之后，兔允许不受限制的笼活动16周。与对照动物相比，用Rosiglitazone处理的兔肢体的挛缩角度显示屈曲屈曲性上显着的改善（分别平均角度，64.4度，P <0.03）。在牺牲时（第24周），罗格列唑酮组中的动物继续表现出比对照（119.0度与99.5度，P = 0.014）表现出较少的关节挛缩。使用注入的OPF水凝胶的rosiglitazone的关节内递送降低了节肢动物兔模型中的屈曲挛缩，而不会导致不良反应（例如，炎症或关节炎）。临床意义陈述：创伤后的关节挛缩是常见和衰弱的，有限的可用治疗方案。药理学干预措施可能会妨碍和治疗这种挛缩。该研究是平移的，因为商业批准的药物已通过新型递送装置进行重新灌注。 （c）2018年骨科研究会。由Wiley Hearyicals，Inc.J Orthop Res 36：2949-2955,2018出版。

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