...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of orthopaedic research >Mechanical behavior of metastatic vertebrae are influenced by tissue architecture, mineral content, and organic feature alterations
【24h】

Mechanical behavior of metastatic vertebrae are influenced by tissue architecture, mineral content, and organic feature alterations

机译：转移性椎骨的力学行为受组织建筑，矿物质含量和有机特征改变的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Diminished vertebral mechanical behavior with metastatic involvement is typically attributed to modified architecture and trabecular bone content. Previous work has identified organic and mineral phase bone quality changes in the presence of metastases, yet limited work exists on the potential influence of such tissue level modifications on vertebral mechanical characteristics. This work seeks to determine correlations between features of bone (structural and tissue level) and mechanical behavior in metastatically involved vertebral bone. It is hypothesized that tissue level properties (mineral and organic) will improve these correlations beyond architectural properties and BMD alone. Twenty-four female athymic rats were inoculated with HeLa or Ace-1 cancer cells lines producing osteolytic (N = 8) or mixed (osteolytic/osteoblastic, N = 7) metastases, respectively. Twenty-one days post-inoculation L1-L3 pathologic vertebral motion segments were excised and mu CT imaged. 3D morphometric parameters and axial rigidity of the L2 vertebrae were quantified. Sequential loading and mu CT imaging measured progression of failure, stiffness and peak force. Relationships between mechanical testing (whole bone and tissue-level) and tissue-level material property modifications with metastatic involvement were evaluated utilizing linear regression models. Osteolytic involvement reduced vertebral trabecular bone volume, structure, CT-derived axial rigidity, stiffness and failure force compared to healthy controls (N = 9). Mixed metastases demonstrated similar trends. Previously assessed collagen cross-linking and proline-based residues were correlated to mechanical behavior and improved the predictive ability of the regression models. Similarly, collagen organization improved predictive regression models for metastatic bone hardness. This work highlights the importance of both bone content/architecture and organic tissue-level features in characterizing metastatic vertebral mechanics. (c) 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:3013-3022, 2018.
机译：具有转移性受累的椎体力学行为减少通常归因于改进的架构和小梁骨含量。先前的工作已经确定了转移存在下存在的有机和矿物相骨质变化，但在这种组织水平修饰对椎体机械特性的潜在影响，存在有限的工作。这项工作寻求确定骨骼（结构和组织水平）的特征与术中涉及椎骨骨骼的力学行为之间的相关性。假设组织水平性质（矿物质和有机）将改善超出架构性质和BMD的这些相关性。用Hela或Ace-1癌细胞系分别接种二十四只雌性无甲醛大鼠，其分别产生骨溶胶（n = 8）或混合（骨解/骨细胞，n = 7）转移的转移。切割后二十一天的接种后L1-L3病理椎体运动段并成像。量化L2椎骨的3D形貌参数和轴向刚度。顺序加载和MU CT成像测量失败，刚度和峰值力的进展。利用线性回归模型评估机械测试（全骨和组织级）和组织级材料性能修饰之间的关系。与健康对照相比，骨溶解涉及降低椎骨小梁骨体积，结构，CT衍生的轴向刚度，刚度和破坏力（n = 9）。混合转移呈现类似的趋势。以前评估的胶原蛋白交联和基于脯氨酸基残留物与机械行为相关，并改善了回归模型的预测能力。同样，胶原蛋白组织改进了转移性骨硬度的预测性回归模型。这项工作突出了骨内容/建筑和有机组织级特征在表征转移性椎体力学中的重要性。 （c）2018年骨科研究会。由Wiley期刊出版，Inc.J Orthop Res 36：3013-3022，2018。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号