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首页> 外文期刊>Journal of orthopaedic research >Investigating gender and ethnicity differences in proximal humeral morphology using a statistical shape model
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Investigating gender and ethnicity differences in proximal humeral morphology using a statistical shape model

机译：使用统计形状模型调查近端肱骨形态的性别和种族差异

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摘要

Morphological variability in the shoulder influences the joint biomechanics and is an important consideration in arthroplasty and implant design. The objectives of this study were to quantify cortical and cancellous proximal humeral morphology and to assess whether shape variation was influenced by gender and ethnicity, with the overarching goal of informing implant design and treatment. A statistical shape model of the proximal humeral cortical and cancellous regions was developed for a training set of 84 subjects of both genders and different ethnicities. Cortical and cancellous bone geometries were reconstructed from CT scans, meshed with triangular elements, and registered to a template. Principal component analysis was applied to quantify modes of variation. Anatomical measurements were computed on the registered geometries to assess correlation with modes of variation. Parallel analysis identified six significant modes of variation, which accounted for 93% of variation in the training set and described scaling (Mode 1), inclination of the head (Modes 2 and 5), and shape of the greater tuberosity and neck region (Modes 3, 4, and 6). Size differences as described by Mode 1 were statistically significant for gender and ethnicity, where female and Asian subjects were smaller than male and Caucasian subjects, respectively; however, differences in other modes were not significant. Cortical thickness of the shaft after normalization by outer diameter was significantly larger for Asian subjects compared to Caucasian subjects. The statistical shape model quantified cortical and cancellous humeral morphology considering gender and ethnicity, providing descriptive data to support surgical planning, and implant design. (c) 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:3043-3052, 2018.
机译：肩部的形态变异性影响关节生物力学，是关节成形术和植入物设计中的重要考虑因素。本研究的目标是量化皮质和松散的近端肱骨形态，并评估形状变异是否受到性别和种族的影响，其总体目标是通知植入物设计和治疗。开发了近端肱骨皮质和松散地区的​​统计形状模型，为一个训练和不同种族的84个科目的训练组。从CT扫描重建皮质和松质骨头几何形状，用三角形元素啮合，并注册到模板。应用主成分分析来量化变异模式。在登记的几何形状上计算解剖学测量以评估与变化模式的相关性。并行分析确定了六种显着的变化模式，其占训练集的93％的变化和描述的缩放（模式1），头部（模式2和5）的倾斜度，以及较大的结节和颈部区域的形状（模式3,4和6）。 Mode 1所述的大小差异对于性别和种族具有统计学意义，分别比男性和亚洲受试者小于雄性和白种人受试者;然而，其他模式的差异并不重要。与白种人受试者相比，亚洲受试者的外径归一化后轴的皮质厚度显着较大。考虑性别和种族的统计形状模型量化皮质和松质肱骨形态，提供了描述数据，以支持手术规划和植入性设计。 （c）2018年骨科研究会。由Wiley Hearyicals，Inc.J orthop Res 36：3043-3052，2018年出版。

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